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COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study.
D'Souza, Gypsyamber; Springer, Gayle; Gustafson, Deborah; Kassaye, Seble; Alcaide, Maria L; Ramirez, Catalina; Sharma, Anjali; Palella, Frank J; Tien, Phyllis C; Detels, Roger; Kempf, Mirjam-Colette; Lahiri, Cecile D; Rinaldo, Charles R; French, Audrey L; Margolick, Joseph B; Adimora, Ada A.
  • D'Souza G; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Springer G; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Gustafson D; Department of Neurology, State of New York Downstate Health Sciences University, Brooklyn, NY, USA.
  • Kassaye S; Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington, DC, USA.
  • Alcaide ML; Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Fl, USA.
  • Ramirez C; Department of Medicine, UNC School Division of Medicine, The Infectious Diseases, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Sharma A; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Palella FJ; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Tien PC; Department of Medicine, University of California, San Francisco and Department of Veterans Affairs, San Francisco, CA, USA.
  • Detels R; Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
  • Kempf MC; Schools of Nursing, Public Health and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Lahiri CD; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
  • Rinaldo CR; Department of Infectious Diseases and Microbiology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • French AL; Department of Medicine, CORE Center/Stroger Hospital of Cook County, Chicago, IL, USA.
  • Margolick JB; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Adimora AA; Department of Medicine, UNC School Division of Medicine, The Infectious Diseases, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
HIV Res Clin Pract ; 21(5): 130-139, 2020 10.
Article in English | MEDLINE | ID: covidwho-933809
Semantic information from SemMedBD (by NLM)
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ABSTRACT

BACKGROUND:

SARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described.

OBJECTIVE:

To study COVID-19 symptoms and SARS-CoV-2 PCR-based swab testing among participants of the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS).

METHODS:

A telephone survey was collected April-June 30, 2020. Symptom and testing prevalence were explored. Multivariable logistic regression was used to examine the factors associated with SARS-CoV-2 positivity.

RESULTS:

The survey was completed by 3411 participants, including 2078 (61%) PLWH and 1333 HIV-seronegative (SN) participants from across the US. Thirteen percent (n = 441) were tested for SARS-CoV-2 infection (13.4% of PLWH vs 12.2% of SN). Among those tested, positivity was higher in PLWH than SN (11.2% vs 6.1%, p = 0.08). Reasons for not being tested included testing not being available (30% of participants) and not knowing where to get tested (16% of participants). Most symptoms reported since January 2020 were similar in PLWH and SN, including headache (23% vs. 24%), myalgias (19% vs 18%), shortness of breath (14% vs 13%), chills (12% vs 10%), fever (6% vs 6%) and loss of taste or smell (6% vs 7%). Among PLWH who tested positive for SARS-CoV-2 DNA, the most common symptoms were headache (71%), myalgia (68%), cough (68%) and chills (65%). In multivariable analysis among those tested, the odds of SARS-CoV-2 positivity were higher among PLWH than SN (aOR = 2.22 95%CI = 01.01-4.85, p = 0.046) and among those living with others versus living alone (aOR = 2.95 95%CI = 1.18-7.40).

CONCLUSION:

Prevalence and type of COVID-19 symptoms were similar in PLWH and SN. SARS-CoV-2 infection may be elevated among PLWH.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Middle aged Country/Region as subject: North America Language: English Journal: HIV Res Clin Pract Year: 2020 Document Type: Article Affiliation country: 25787489.2020.1844521

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Female / Humans / Middle aged Country/Region as subject: North America Language: English Journal: HIV Res Clin Pract Year: 2020 Document Type: Article Affiliation country: 25787489.2020.1844521