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The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions.
Perfetto, L; Pastrello, C; Del-Toro, N; Duesbury, M; Iannuccelli, M; Kotlyar, M; Licata, L; Meldal, B; Panneerselvam, K; Panni, S; Rahimzadeh, N; Ricard-Blum, S; Salwinski, L; Shrivastava, A; Cesareni, G; Pellegrini, M; Orchard, S; Jurisica, I; Hermjakob, H; Porras, P.
  • Perfetto L; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Pastrello C; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
  • Del-Toro N; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Duesbury M; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Iannuccelli M; UCLA-DOE Institute, UCLA, Los Angeles, CA 90095, USA.
  • Kotlyar M; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, 00133, Italy.
  • Licata L; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
  • Meldal B; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, 00133, Italy.
  • Panneerselvam K; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Panni S; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Rahimzadeh N; Department of Biology, Ecology and Earth Sciences, Università della Calabria, Rende, 87036, Italy.
  • Ricard-Blum S; UCLA-DOE Institute, UCLA, Los Angeles, CA 90095, USA.
  • Salwinski L; Providence John Wayne Cancer Institute, Department of Translational Molecular, Santa Monica, CA 90404, USA.
  • Shrivastava A; Univ Lyon, University Claude Bernard Lyon 1, INSA Lyon, CPE, Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), UMR 5246, F-69622 Villeurbanne, 69622, France.
  • Cesareni G; UCLA-DOE Institute, UCLA, Los Angeles, CA 90095, USA.
  • Pellegrini M; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Orchard S; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, 00133, Italy.
  • Jurisica I; Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095, USA .
  • Hermjakob H; European Molecular Biology Laboratory, Wellcome Genome Campus, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK.
  • Porras P; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.
Database (Oxford) ; 20202020 01 01.
Article in English | MEDLINE | ID: covidwho-933843
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ABSTRACT
The current coronavirus disease of 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2, has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are being used to understand the disease and develop effective treatments, the study of physical molecular interactions can provide fine-grained resolution of the mechanisms behind the virus biology and the human organism response. We present a curated dataset of physical molecular interactions focused on proteins from SARS-CoV-2, SARS-CoV-1 and other members of the Coronaviridae family that has been manually extracted by International Molecular Exchange (IMEx) Consortium curators. Currently, the dataset comprises over 4400 binarized interactions extracted from 151 publications. The dataset can be accessed in the standard formats recommended by the Proteomics Standards Initiative (HUPO-PSI) at the IntAct database website (https//www.ebi.ac.uk/intact) and will be continuously updated as research on COVID-19 progresses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronaviridae / Host-Pathogen Interactions / Pandemics / Protein Interaction Maps / Betacoronavirus Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Database

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronaviridae / Host-Pathogen Interactions / Pandemics / Protein Interaction Maps / Betacoronavirus Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Database