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Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls.
Venkatesulu, Bhanu P; Lester, Scott; Hsieh, Cheng-En; Verma, Vivek; Sharon, Elad; Ahmed, Mansoor; Krishnan, Sunil.
  • Venkatesulu BP; Department of Radiation Oncology, Loyola University Stritch School of Medicine, Chicago, IL, USA.
  • Lester S; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
  • Hsieh CE; Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA.
  • Verma V; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
  • Sharon E; Radiation Research Program, Division Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA.
  • Ahmed M; Cancer Therapy Evaluation Program, Division Cancer Treatment and Diagnosis National Cancer Institute, Bethesda, MD, USA.
  • Krishnan S; Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
JNCI Cancer Spectr ; 5(1): pkaa103, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-933863
ABSTRACT
The coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has exacted an enormous toll on healthcare systems worldwide. The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients. The sparsity of viable treatment options for this viral infection and the sequelae of pulmonary complications have fueled the quest for new therapeutic considerations. One such option, the long-forgotten idea of using low-dose radiation therapy, has recently found renewed interest in many academic centers. We outline the scientific and logistical rationale for consideration of this option and the mechanistic underpinnings of any potential therapeutic value, particularly as viewed from an immunological perspective. We also discuss the preliminary and/or published results of prospective trials examining low-dose radiation therapy for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Dosage / Virus Replication / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: JNCI Cancer Spectr Year: 2021 Document Type: Article Affiliation country: Jncics

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Radiation Dosage / Virus Replication / Virus Internalization / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: JNCI Cancer Spectr Year: 2021 Document Type: Article Affiliation country: Jncics