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Multiple potential targets of opioids in the treatment of acute respiratory distress syndrome from COVID-19.
Cismaru, Cosmin Andrei; Cismaru, Gabriel Laurentiu; Nabavi, Seyed Fazel; Ghanei, Mostafa; Burz, Claudia Cristina; Nabavi, Seyed Mohammad; Berindan Neagoe, Ioana.
  • Cismaru CA; Research Center for Functional Genomics, Biomedicine and Translational Medicine, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Cismaru GL; Department of Functional Sciences, Immunology and Allergology, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Nabavi SF; Department of Internal Medicine, Cardiology-Rehabilitation, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Ghanei M; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Burz CC; Chemical Injuries Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Nabavi SM; Department of Functional Sciences, Immunology and Allergology, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Berindan Neagoe I; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Cell Mol Med ; 25(1): 591-595, 2021 01.
Article in English | MEDLINE | ID: covidwho-934013
ABSTRACT
COVID-19 can present with a variety of clinical features, ranging from asymptomatic or mild respiratory symptoms to fulminant acute respiratory distress syndrome (ARDS) depending on the host's immune responses and the extent of the associated pathologies. This implies that several measures need to be taken to limit severely impairing symptoms caused by viral-induced pathology in vital organs. Opioids are most exploited for their analgesic effects but their usage in the palliation of dyspnoea, immunomodulation and lysosomotropism may represent potential usages of opioids in COVID-19. Here, we describe the mechanisms involved in each of these potential usages, highlighting the benefits of using opioids in the treatment of ARDS from SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 / COVID-19 Drug Treatment / Analgesics, Opioid Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jcmm.15927

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 / COVID-19 Drug Treatment / Analgesics, Opioid Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jcmm.15927