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A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study.
Doulou, Sarantia; Leventogiannis, Konstantinos; Tsilika, Maria; Rodencal, Matthew; Katrini, Konstantina; Antonakos, Nikolaos; Kyprianou, Miltiades; Karofylakis, Emmanouil; Karageorgos, Athanassios; Koufargyris, Panagiotis; Christopoulos, Gennaios; Kassianidis, George; Stamatelopoulos, Kimon; Newberry, Robert; Giamarellos-Bourboulis, Evangelos J.
  • Doulou S; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Leventogiannis K; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Tsilika M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Rodencal M; Sanmina Corporation, 13000 S. Memorial Parkway, Huntsville, AL, 35803, USA.
  • Katrini K; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Antonakos N; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Kyprianou M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Karofylakis E; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Karageorgos A; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Koufargyris P; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Christopoulos G; 2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece.
  • Kassianidis G; Intensive Care Unit, Korgialeneion Benakeion Athens General Hospital, 115 26, Athens, Greece.
  • Stamatelopoulos K; Department of Therapeutics, National and Kapodistrian University of Athens, 115 28, Athens, Greece.
  • Newberry R; Sanmina Corporation, 13000 S. Memorial Parkway, Huntsville, AL, 35803, USA.
  • Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62, Athens, Greece. egiamarel@med.uoa.gr.
BMC Infect Dis ; 20(1): 860, 2020 Nov 19.
Article in English | MEDLINE | ID: covidwho-934260
ABSTRACT

BACKGROUND:

The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied.

METHODS:

The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were done every two hours for three consecutive days after hospital admission in 142 patients at high-risk for sepsis by placing the OB on the forefinger. At the second phase, single recordings were done in 54 patients with symptoms of viral infection; 38 were diagnosed with COVID-19.

RESULTS:

At the first phase, the cutoff value of positive likelihood of 18 provided 100% specificity and 100% positive predictive value for the diagnosis of sepsis. These were 87.5 and 91.7% respectively at the second phase. OB diagnosed severe COVID-19 with 83.3% sensitivity and 87.5% negative predictive value.

CONCLUSIONS:

The studied OB seems valuable for the discrimination of infection severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Biosensing Techniques / Coronavirus Infections / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05607-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Biosensing Techniques / Coronavirus Infections / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05607-1