Addressing the Importance of Stem Cell-Based Therapy: A Perspective in the Treatment of COVID-19.
Curr Mol Med
; 21(6): 441-456, 2021.
Article
in English
| MEDLINE | ID: covidwho-934391
ABSTRACT
Severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan, China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO), pointing to the over 118000 cases of Coronavirus disease 2019 (COVID-19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases, but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview of the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stem Cells
/
Cell- and Tissue-Based Therapy
/
COVID-19
/
COVID-19 Drug Treatment
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
Curr Mol Med
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
1566524020999201117120147
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