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Repurposing Screens of FDA-Approved Drugs Identify 29 Inhibitors of SARS-CoV-2.
Ku, Keun Bon; Shin, Hye Jin; Kim, Hae Soo; Kim, Bum-Tae; Kim, Seong-Jun; Kim, Chonsaeng.
  • Ku KB; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Shin HJ; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Kim HS; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Kim BT; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Kim SJ; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Kim C; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
J Microbiol Biotechnol ; 30(12): 1843-1853, 2020 Dec 28.
Article in English | MEDLINE | ID: covidwho-934537
ABSTRACT
COVID-19, caused by the novel coronavirus SARS-CoV-2, has spread globally and caused serious social and economic problems. The WHO has declared this outbreak a pandemic. Currently, there are no approved vaccines or antiviral drugs that prevent SARS-CoV-2 infection. Drugs already approved for clinical use would be ideal candidates for rapid development as COVID-19 treatments. In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs among those tested showed antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Approval / Drug Repositioning / SARS-CoV-2 Type of study: Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: North America Language: English Journal: J Microbiol Biotechnol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Approval / Drug Repositioning / SARS-CoV-2 Type of study: Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: North America Language: English Journal: J Microbiol Biotechnol Year: 2020 Document Type: Article