Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.
Nat Rev Cardiol
; 18(3): 194-209, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-936141
ABSTRACT
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive inflammation and respiratory disease, with cytokine storm and acute respiratory distress syndrome implicated in the most severe cases. Thrombotic complications are a major cause of morbidity and mortality in patients with COVID-19. Patients with pre-existing cardiovascular disease and/or traditional cardiovascular risk factors, including obesity, diabetes mellitus, hypertension and advanced age, are at the highest risk of death from COVID-19. In this Review, we summarize new lines of evidence that point to both platelet and endothelial dysfunction as essential components of COVID-19 pathology and describe the mechanisms that might account for the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19. We highlight the distinct contributions of coagulopathy, thrombocytopathy and endotheliopathy to the pathogenesis of COVID-19 and discuss potential therapeutic strategies in the management of patients with COVD-19. Harnessing the expertise of the biomedical and clinical communities is imperative to expand the available therapeutics beyond anticoagulants and to target both thrombocytopathy and endotheliopathy. Only with such collaborative efforts can we better prepare for further waves and for future coronavirus-related pandemics.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombosis
/
Blood Coagulation Disorders
/
Blood Platelet Disorders
/
Endothelium, Vascular
/
COVID-19
/
Inflammation
Type of study:
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Nat Rev Cardiol
Journal subject:
Cardiology
Year:
2021
Document Type:
Article
Affiliation country:
S41569-020-00469-1
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