The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
Gastroenterology
; 160(1): 39-46, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-936157
ABSTRACT
The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, Virus
/
Gastrointestinal Microbiome
/
Gastroenteritis
/
Angiotensin-Converting Enzyme 2
/
SARS-CoV-2
/
COVID-19
/
Intestinal Mucosa
Limits:
Animals
/
Humans
Language:
English
Journal:
Gastroenterology
Year:
2021
Document Type:
Article
Affiliation country:
J.gastro.2020.07.067
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