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Effectiveness of infection-containment measures on SARS-CoV-2 seroprevalence and circulation from May to July 2020, in Milan, Italy.
Cento, Valeria; Alteri, Claudia; Merli, Marco; Di Ruscio, Federica; Tartaglione, Livia; Rossotti, Roberto; Travi, Giovanna; Vecchi, Marta; Raimondi, Alessandro; Nava, Alice; Colagrossi, Luna; Fumagalli, Roberto; Ughi, Nicola; Epis, Oscar Massimiliano; Fanti, Diana; Beretta, Andrea; Galbiati, Filippo; Scaglione, Francesco; Vismara, Chiara; Puoti, Massimo; Campisi, Daniela; Perno, Carlo Federico.
  • Cento V; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Alteri C; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Merli M; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Di Ruscio F; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Tartaglione L; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Rossotti R; Residency in Microbiology and Virology, Università degli Studi di Milano, Milan, Italy.
  • Travi G; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Vecchi M; Residency in Microbiology and Virology, Università degli Studi di Milano, Milan, Italy.
  • Raimondi A; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Nava A; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Colagrossi L; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Fumagalli R; Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Ughi N; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Epis OM; Residency in Microbiology and Virology, Università degli Studi di Milano, Milan, Italy.
  • Fanti D; Department of Anesthesiology, Critical Care and Pain Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Beretta A; Rheumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Galbiati F; Rheumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Scaglione F; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Vismara C; Emergency Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Puoti M; Emergency Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Campisi D; Chemical-Clinical and Microbiological Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Perno CF; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
PLoS One ; 15(11): e0242765, 2020.
Article in English | MEDLINE | ID: covidwho-937237
ABSTRACT

OBJECTIVE:

Through a hospital-based SARS-CoV-2 molecular and serological screening, we evaluated the effectiveness of two months of lockdown and two of surveillance, in Milan, Lombardy, the first to be overwhelmed by COVID-19 pandemics during March-April 2020.

METHODS:

All subjects presenting at the major hospital of Milan from May-11 to July-5, 2020, underwent a serological screening by chemiluminescent assays. Those admitted were further tested by RT-PCR.

RESULTS:

The cumulative anti-N IgG seroprevalence in the 2753 subjects analyzed was of 5.1% (95%CI = 4.3%-6.0%), with a peak of 8.4% (6.1%-11.4%) 60-63 days since the peak of diagnoses (March-20). 31/106 (29.2%) anti-N reactive subjects had anti-S1/S2 titers >80 AU/mL. Being tested from May-18 to June-5, or residing in the provinces with higher SARS-CoV-2 circulation, were positively and independently associated with anti-N IgG reactivity (OR [95%CI] 2.179[1.455-3.264] and 3.127[1.18-8.29], respectively). In the 18 RT-PCR positive, symptomatic subjects, anti-N seroprevalence was 33.3% (95% CI 14.8%-56.3%).

CONCLUSION:

SARS-CoV-2 seroprevalence in Milan is low, and in a downward trend after only 60-63 days since the peak of diagnoses. Italian confinement measures were effective, but the risk of contagion remains concrete. In hospital-settings, the performance of molecular and serological screenings upon admission remains highly advisable.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Communicable Disease Control / Coronavirus Infections / Pandemics Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0242765

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Communicable Disease Control / Coronavirus Infections / Pandemics Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0242765