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Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence.
Bohn, Mary Kathryn; Lippi, Giuseppe; Horvath, Andrea; Sethi, Sunil; Koch, David; Ferrari, Maurizio; Wang, Cheng-Bin; Mancini, Nicasio; Steele, Shannon; Adeli, Khosrow.
  • Bohn MK; Clinical Biochemistry, DPLM, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Lippi G; IFCC Taskforce on COVID-19, International Federation of Clinical Chemistry, Milan, Italy.
  • Horvath A; Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
  • Sethi S; IFCC Taskforce on COVID-19, International Federation of Clinical Chemistry, Milan, Italy.
  • Koch D; Department of Clinical Chemistry and Endocrinology, New South Wales Health Pathology, Prince of Wales Hospital, Sydney, Australia.
  • Ferrari M; IFCC Taskforce on COVID-19, International Federation of Clinical Chemistry, Milan, Italy.
  • Wang CB; Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
  • Mancini N; IFCC Taskforce on COVID-19, International Federation of Clinical Chemistry, Milan, Italy.
  • Steele S; Department of Pathology and Laboratory Medicine, Emory University, and Director of Clinical Chemistry, Grady Memorial Hospital, Atlanta, Georgia, United States.
  • Adeli K; IFCC Taskforce on COVID-19, International Federation of Clinical Chemistry, Milan, Italy.
Clin Chem Lab Med ; 58(7): 1037-1052, 2020 06 25.
Article in English | MEDLINE | ID: covidwho-937253
ABSTRACT
The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. Initial response to this pandemic involved the development, production, and distribution of diagnostic molecular assays at an unprecedented rate, leading to minimal validation requirements and concerns regarding their diagnostic accuracy in clinical settings. In addition to molecular testing, serological assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now becoming available from numerous diagnostic manufacturers. In both cases, the lack of peer-reviewed data and regulatory oversight, combined with general misconceptions regarding their appropriate use, have highlighted the importance of laboratory professionals in robustly validating and evaluating these assays for appropriate clinical use. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management. This review summarizes the latest evidence and status of molecular, serological, and biochemical testing in COVID-19 and highlights some key considerations for clinical laboratories operating to support the global fight against this ongoing pandemic. Confidently this consolidated information provides a useful resource to laboratories and a reminder of the laboratory's critical role as the world battles this unprecedented crisis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2020 Document Type: Article Affiliation country: Cclm-2020-0722

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2020 Document Type: Article Affiliation country: Cclm-2020-0722