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COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study.
Longobardo, Alessia; Snow, Timothy Arthur Chandos; Montanari, Cecilia; Shulman, Robert; Singer, Mervyn; Arulkumaran, Nishkantha.
  • Longobardo A; Bloomsbury Institute of Intensive Care Medicine, University College London, UK.
  • Snow TAC; Bloomsbury Institute of Intensive Care Medicine, University College London, UK.
  • Montanari C; Bloomsbury Institute of Intensive Care Medicine, University College London, UK.
  • Shulman R; Bloomsbury Institute of Intensive Care Medicine, University College London, UK.
  • Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, UK.
  • Arulkumaran N; Bloomsbury Institute of Intensive Care Medicine, University College London, UK. Electronic address: nisharulkumaran@doctors.org.uk.
J Crit Care ; 62: 46-48, 2021 04.
Article in English | MEDLINE | ID: covidwho-939047
ABSTRACT
Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO2 FiO2 ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Steroids / COVID-19 / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Crit Care Journal subject: Critical Care Year: 2021 Document Type: Article Affiliation country: J.jcrc.2020.11.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Steroids / COVID-19 / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Crit Care Journal subject: Critical Care Year: 2021 Document Type: Article Affiliation country: J.jcrc.2020.11.012