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Dendritic cell vaccine immunotherapy; the beginning of the end of cancer and COVID-19. A hypothesis.
Saadeldin, Mona Kamal; Abdel-Aziz, Amal Kamal; Abdellatif, Ahmed.
  • Saadeldin MK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy. Electronic address: m.kamal@aucegypt.edu.
  • Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • Abdellatif A; Biology Department, School of Science and Engineering, American University in Cairo, New Cairo 11835, Egypt. Electronic address: ahmed.abdellatif@aucegypt.edu.
Med Hypotheses ; 146: 110365, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-939146
ABSTRACT
Immunotherapy is the newest approach to combat cancer. It can be achieved using several strategies, among which is the dendritic cell (DC) vaccine therapy. Several clinical trials are ongoing using DC vaccine therapy either as a sole agent or in combination with other interventions to tackle different types of cancer. Immunotherapy can offer a potential treatment to coronavirus disease 2019 (COVID-19) the worst pandemic facing this generation, a disease with deleterious effects on the health and economic systems worldwide. We hypothesize that DC vaccine therapy may provide a potential treatment strategy to help combat COVID-19. Cancer patients are at the top of the vulnerable population owing to their immune-compromised status. In this review, we discuss DC vaccine therapy in the light of the body's immunity, cancer, and newly emerging infections such as COVID-19 in hopes of better-customized treatment options for patients with multiple comorbidities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / Models, Immunological / COVID-19 / Immunotherapy / Neoplasms Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / Models, Immunological / COVID-19 / Immunotherapy / Neoplasms Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article