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Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019.
Lee, Jee-Soo; Kim, So Yeon; Kim, Taek Soo; Hong, Ki Ho; Ryoo, Nam-Hee; Lee, Jaehyeon; Park, Jae Hyeon; Cho, Sung Im; Kim, Man Jin; Kim, Young-Gon; Kim, Boram; Shin, Ho Seob; Oh, Hyeon Sae; Seo, Myoung-Seock; Gwon, Tae-Rin; Kim, Yeonjae; Park, Jun-Sun; Chin, Bum Sik; Park, Wan Beom; Park, Sung Sup; Seong, Moon-Woo.
  • Lee JS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim SY; Department of Laboratory Medicine, National Medical Center, Seoul, South Korea.
  • Kim TS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Hong KH; Department of Laboratory Medicine, Seoul Medical Center, Seoul, South Korea.
  • Ryoo NH; Department of Laboratory Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
  • Lee J; Department of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea.
  • Park JH; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Cho SI; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim MJ; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim YG; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim B; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Shin HS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Oh HS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Seo MS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Gwon TR; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim Y; Department of Infectious Disease, National Medical Center, Seoul, South Korea.
  • Park JS; Research Institute of Public Health, National Medical Center, Seoul, South Korea.
  • Chin BS; Department of Infectious Disease, National Medical Center, Seoul, South Korea.
  • Park WB; Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Park SS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
  • Seong MW; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Clin Infect Dis ; 73(9): e3002-e3008, 2021 11 02.
Article in English | MEDLINE | ID: covidwho-939552
ABSTRACT

BACKGROUND:

Positive results from real-time reverse-transcription polymerase chain reaction (rRT-PCR) in recovered patients raise concern that patients who recover from coronavirus disease 2019 (COVID-19) may be at risk of reinfection. Currently, however, evidence that supports reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been reported.

METHODS:

We conducted whole-genome sequencing of the viral RNA from clinical specimens at the initial infection and at the positive retest from 6 patients who recovered from COVID-19 and retested positive for SARS-CoV-2 via rRT-PCR after recovery. A total of 13 viral RNAs from the patients' respiratory specimens were consecutively obtained, which enabled us to characterize the difference in viral genomes between initial infection and positive retest.

RESULTS:

At the time of the positive retest, we were able to acquire a complete genome sequence from patient 1, a 21-year-old previously healthy woman. In this patient, through the phylogenetic analysis, we confirmed that the viral RNA of positive retest was clustered into a subgroup distinct from that of the initial infection, suggesting that there was a reinfection of SARS-CoV-2 with a subtype that was different from that of the primary strain. The spike protein D614G substitution that defines the clade "G" emerged in reinfection, while mutations that characterize the clade "V" (ie, nsp6 L37F and ORF3a G251V) were present at initial infection.

CONCLUSIONS:

Reinfection with a genetically distinct SARS-CoV-2 strain may occur in an immunocompetent patient shortly after recovery from mild COVID-19. SARS-CoV-2 infection may not confer immunity against a different SARS-CoV-2 strain.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Young adult Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Young adult Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid