Your browser doesn't support javascript.
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project).
Korang, Steven Kwasi; Juul, Sophie; Nielsen, Emil Eik; Feinberg, Joshua; Siddiqui, Faiza; Ong, Giok; Klingenberg, Sarah; Veroniki, Areti Angeliki; Bu, Fanlong; Thabane, Lehana; Thomsen, Allan Randrup; Jakobsen, Janus C; Gluud, Christian.
  • Korang SK; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. steven.korang@ctu.dk.
  • Juul S; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Nielsen EE; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Feinberg J; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Siddiqui F; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Ong G; Systematic Review Initiative, NHS Blood and Transplant, John Radcliffe Hospital, Headley Way, Oxford, OX3 9BQ, UK.
  • Klingenberg S; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Veroniki AA; The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Bu F; Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
  • Thabane L; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Thomsen AR; Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Jakobsen JC; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
  • Gluud C; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Syst Rev ; 9(1): 262, 2020 11 20.
Article in English | MEDLINE | ID: covidwho-940035
Semantic information from SemMedBD (by NLM)
1. Vaccines PREVENTS COVID-19
Subject
Vaccines
Predicate
PREVENTS
Object
COVID-19
2. RN PREVENTS C5203670
Subject
RN
Predicate
PREVENTS
Object
C5203670
3. CD69 protei PREVENTS C5203670
Subject
CD69 protei
Predicate
PREVENTS
Object
C5203670
4. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
5. CD69 protei compared_with C0035696
Subject
CD69 protei
Predicate
compared_with
Object
C0035696
6. Vaccines PREVENTS COVID-19
Subject
Vaccines
Predicate
PREVENTS
Object
COVID-19
7. RNA, Messenger PREVENTS COVID-19
Subject
RNA, Messenger
Predicate
PREVENTS
Object
COVID-19
8. CD69 protein, human|CD69 PREVENTS COVID-19
Subject
CD69 protein, human|CD69
Predicate
PREVENTS
Object
COVID-19
9. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
10. CD69 protein, human|CD69 compared_with RNA, Messenger
Subject
CD69 protein, human|CD69
Predicate
compared_with
Object
RNA, Messenger
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) which has rapidly spread worldwide. Several human randomized clinical trials assessing potential vaccines are currently underway. There is an urgent need for a living systematic review that continuously assesses the beneficial and harmful effects of all available vaccines for COVID-19. METHODS/

DESIGN:

We will conduct a living systematic review based on searches of major medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify relevant randomized clinical trials. We will update the literature search once a week to continuously assess if new evidence is available. Two review authors will independently extract data and conduct risk of bias assessments. We will include randomized clinical trials comparing any vaccine aiming to prevent COVID-19 (including but not limited to messenger RNA; DNA; non-replicating viral vector; replicating viral vector; inactivated virus; protein subunit; dendritic cell; other vaccines) with any comparator (placebo; "active placebo;" no intervention; standard care; an "active" intervention; another vaccine for COVID-19) for participants in all age groups. Primary outcomes will be all-cause mortality; a diagnosis of COVID-19; and serious adverse events. Secondary outcomes will be quality of life and non-serious adverse events. The living systematic review will include aggregate data meta-analyses, trial sequential analyses, network meta-analyses, and individual patient data meta-analyses. Within-study bias will be assessed using Cochrane risk of bias tool. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) and Confidence in Network Meta-Analysis (CINeMA) approaches will be used to assess certainty of evidence. Observational studies describing harms identified during the search for trials will also be included and described and analyzed separately.

DISCUSSION:

COVID-19 has become a pandemic with substantial mortality. A living systematic review assessing the beneficial and harmful effects of different vaccines is urgently needed. This living systematic review will regularly inform best practice in vaccine prevention and clinical research of this highly prevalent disease. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42020196492.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Controlled clinical trial / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Syst Rev Year: 2020 Document Type: Article Affiliation country: S13643-020-01516-1

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Controlled clinical trial / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Syst Rev Year: 2020 Document Type: Article Affiliation country: S13643-020-01516-1