Your browser doesn't support javascript.
Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease.
Summer, Kate; Browne, Jessica; Liu, Lei; Benkendorff, Kirsten.
  • Summer K; Marine Ecology Research Centre, School of Environment, Science and Engineering, Southern Cross University, GPO Box 157, Lismore, NSW 2480, Australia.
  • Browne J; School of Health and Human Sciences, Southern Cross University, Terminal Drive, Bilinga, QLD 4225, Australia.
  • Liu L; Southern Cross Plant Science, Southern Cross University, GPO Box 157, Lismore, NSW 2480, Australia.
  • Benkendorff K; National Marine Science Centre, Southern Cross University, 2 Bay Drive, Coffs Harbour, NSW 2450, Australia.
Mar Drugs ; 18(11)2020 Nov 19.
Article in English | MEDLINE | ID: covidwho-940583
ABSTRACT
Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Diseases / Anti-Inflammatory Agents / Mollusca Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Traditional medicine Limits: Animals / Humans Language: English Journal subject: Biology / Pharmacology Year: 2020 Document Type: Article Affiliation country: Md18110570

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Diseases / Anti-Inflammatory Agents / Mollusca Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Traditional medicine Limits: Animals / Humans Language: English Journal subject: Biology / Pharmacology Year: 2020 Document Type: Article Affiliation country: Md18110570