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Coagulopathy in patients with COVID-19: a systematic review and meta-analysis.
Zhang, Xiaolin; Yang, Xue; Jiao, Hongmei; Liu, Xinmin.
  • Zhang X; Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
  • Yang X; Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
  • Jiao H; Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
  • Liu X; Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
Aging (Albany NY) ; 12(24): 24535-24551, 2020 11 24.
Article in English | MEDLINE | ID: covidwho-940615
ABSTRACT
COVID-19 patients frequently exhibit coagulation abnormalities and thrombotic events. In this meta-analysis, we investigated the association between coagulopathy and the severity of COVID-19 illness. Using PubMed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv, a systematic literature search was conducted for studies published between December 1, 2019 and May 1, 2020. We then analyzed coagulation parameters in COVID-19 patients exhibiting less severe and more severe symptoms. All statistical analyses were performed using Stata14.0 software. A total of 3,952 confirmed COVID-19 patients from 25 studies were included in the meta-analysis. Patients with severe symptoms exhibited higher levels of D-dimer, prothrombin time (PT), and fibrinogen (FIB) than patients with less severe symptoms (SMD 0.83, 95% CI 0.70-0.97, I2 56.9%; SMD 0.39, 95% CI 0.14-0.64, I2 79.4%; and SMD 0.35, 95% CI 0.17-0.53, I2 42.4%, respectively). However, platelet and activated partial thromboplastin times did not differ (SMD -0.26, 95% CI -0.56-0.05, I2 82.2%; and SMD -0.14, 95% CI -0.45-0.18, I2 75.7%, respectively). These findings demonstrate that hypercoagulable coagulopathy is associated with the severity of COVID-19 symptoms and that D-dimer, PT, and FIB values are the main parameters that should be considered when evaluating coagulopathy in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2020 Document Type: Article Affiliation country: Aging.104138

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2020 Document Type: Article Affiliation country: Aging.104138