Your browser doesn't support javascript.
Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure.
King, Christopher S; Sahjwani, Dhwani; Brown, A Whitney; Feroz, Saad; Cameron, Paula; Osborn, Erik; Desai, Mehul; Djurkovic, Svetolik; Kasarabada, Aditya; Hinerman, Rachel; Lantry, James; Shlobin, Oksana A; Ahmad, Kareem; Khangoora, Vikramjit; Aryal, Shambhu; Collins, A Claire; Speir, Alan; Nathan, Steven.
  • King CS; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Sahjwani D; Department of Pediatrics, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Brown AW; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Feroz S; Department of Pediatrics, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Cameron P; Respiratory Therapy Department, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Osborn E; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Desai M; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Djurkovic S; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Kasarabada A; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Hinerman R; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Lantry J; Medical Critical Care Service, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Shlobin OA; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Ahmad K; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Khangoora V; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Aryal S; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Collins AC; Advanced Lung Disease Research, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Speir A; Department of Cardiothoracic Surgery, Inova Fairfax Hospital, Falls Church, VA, United States of America.
  • Nathan S; Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States of America.
PLoS One ; 15(11): e0242651, 2020.
Article in English | MEDLINE | ID: covidwho-940728
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT

PURPOSE:

The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an appropriately resourced US health care system.

METHODS:

Outcomes of COVID-19 infected patients requiring mechanical ventilation treated within the Inova Health System between March 5, 2020 and April 26, 2020 were evaluated through an electronic medical record review.

RESULTS:

1023 COVID-19 positive patients were admitted to the Inova Health System during the study period. Of these, 164 (16.0%) were managed with invasive mechanical ventilation. All patients were followed to definitive disposition. 70/164 patients (42.7%) had died and 94/164 (57.3%) were still alive. Deceased patients were older (median age of 66 vs. 55, p <0.0001) and had a higher initial d-dimer (2.22 vs. 1.31, p = 0.005) and peak ferritin levels (2998 vs. 2077, p = 0.016) compared to survivors. 84.3% of patients over 70 years old died in the hospital. Conversely, 67.4% of patients age 70 or younger survived to hospital discharge. Younger age, non-Caucasian race and treatment at a tertiary care center were all associated with survivor status.

CONCLUSION:

Mortality of patients with COVID-19 requiring invasive mechanical ventilation is high, with particularly daunting mortality seen in patients of advanced age, even in a well-resourced health care system. A substantial proportion of patients requiring invasive mechanical ventilation were not of advanced age, and this group had a reasonable chance for recovery.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Respiratory Insufficiency / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0242651

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Respiratory Insufficiency / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0242651