Effects of work status changes and perceived stress onglycaemiccontrol in individuals with type 1 diabetes during COVID-19 lockdown in Italy.
Diabetes Res Clin Pract
; 170: 108513, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-941224
ABSTRACT
AIMS:
To evaluate the effects of COVID-19 lockdown on blood glucose control in individuals with type 1 diabetes (T1D) and to explore determinants of glucose variability.METHODS:
Fifty T1D patients undergoing continuous/flash glucose monitoring were recruited. The study's primary outcome was the change of time in range (TIR) from before to lockdown period. Three time-point comparisons of TIR, mean glucose levels (MG), estimated (e)HbA1c, time above (TAR) and below range (TBR), moderate/severe hypoglycemic events between pre-lockdown, lockdown and post-lockdown period were also performed. Information on lockdown-associated perceived stress, changes of work status and physical activity were recorded.RESULTS:
TIR significantly decreased (75(63-84)% vs.69(50-76)%,p < 0.001) whereas MG (154 ± 15 mg/dl vs.165 ± 25 mg/dl, p = 0.027) and eHbA1c (7.3(6.6-7.8)%vs.7.5(6.7-8.2)%,p = 0.031) increased from pre- to lockdown period; overall glucose control significantly improved when restriction ended. Lockdown-associated work loss/suspension independently predicted impaired TIR after adjustment for potential confounders (Standardizedß -0.29; 95%CΙ -18.7 to -2.25;p = 0.01). Greater TAR, TBR and hypoglycemic events were also reported during the lockdown.CONCLUSION:
In T1D Italian individuals, blood glucose control significantly worsened during the COVID-19 lockdown; work instability and related issues represented the main determinant of impaired glucose variability in this population.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stress, Psychological
/
Blood Glucose
/
Diabetes Mellitus, Type 1
/
Occupational Stress
/
Glycemic Control
/
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Diabetes Res Clin Pract
Journal subject:
Endocrinology
Year:
2020
Document Type:
Article
Affiliation country:
J.diabres.2020.108513
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