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Impact of Coronavirus Disease 2019 Pandemic on the Incidence and Management of Out-of-Hospital Cardiac Arrest in Patients Presenting With Acute Myocardial Infarction in England.
Rashid Hons, Muhammad; Gale Hons, Chris P; Curzen Hons, Nick; Ludman Hons, Peter; De Belder Hons, Mark; Timmis Hons, Adam; Mohamed Hons, Mohamed O; Lüscher Hons, Thomas F; Hains Hons, Julian; Wu, Jianhua; Shoaib, Ahmad; Kontopantelis, Evangelos; Roebuck, Chris; Denwood, Tom; Deanfield, John; Mamas, Mamas A.
  • Rashid Hons M; Keele Cardiovascular Research Group Institute for Prognosis Research School of Primary Care Keele University Newcastle UK.
  • Gale Hons CP; Department of Cardiology Royal Stoke Hospital Stoke-on-Trent UK.
  • Curzen Hons N; Leeds Institute for Data Analytics University of Leeds Leeds UK.
  • Ludman Hons P; Leeds Teaching Hospitals NHS Trust Leeds UK.
  • De Belder Hons M; Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK.
  • Timmis Hons A; Coronary Research Group University Hospital Southampton and Faculty of Medicine University of Southampton Southampton UK.
  • Mohamed Hons MO; Department of Cardiology Queen Elizabeth Hospital Birmingham Birmingham UK.
  • Lüscher Hons TF; National Institute for Cardiovascular Outcomes Research Barts Health NHS Trust London UK.
  • Hains Hons J; Barts Heart Centre Queen Mary University London London UK.
  • Wu J; Keele Cardiovascular Research Group Institute for Prognosis Research School of Primary Care Keele University Newcastle UK.
  • Shoaib A; Department of Cardiology Royal Stoke Hospital Stoke-on-Trent UK.
  • Kontopantelis E; Royal Brompton and Harefield Hospitals and Imperial College London UK.
  • Roebuck C; Center for Molecular Cardiology University of Zürich Zürich Switzerland.
  • Denwood T; National Institute for Cardiovascular Outcomes Research Barts Health NHS Trust London UK.
  • Deanfield J; Leeds Institute for Data Analytics University of Leeds Leeds UK.
  • Mamas MA; Leeds Teaching Hospitals NHS Trust Leeds UK.
J Am Heart Assoc ; 9(22): e018379, 2020 11 17.
Article in English | MEDLINE | ID: covidwho-941677
Semantic information from SemMedBD (by NLM)
1. Acute myocardial infarction PROCESS_OF Patients
Subject
Acute myocardial infarction
Predicate
PROCESS_OF
Object
Patients
2. Out-of-Hospital Cardiac Arrest OCCURS_IN Patients
Subject
Out-of-Hospital Cardiac Arrest
Predicate
OCCURS_IN
Object
Patients
3. Out-of-Hospital Cardiac Arrest PROCESS_OF Patients
Subject
Out-of-Hospital Cardiac Arrest
Predicate
PROCESS_OF
Object
Patients
4. ST segment elevation myocardial infarction PROCESS_OF Ethnic group
Subject
ST segment elevation myocardial infarction
Predicate
PROCESS_OF
Object
Ethnic group
5. Coronary angiography DIAGNOSES ST segment elevation myocardial infarction
Subject
Coronary angiography
Predicate
DIAGNOSES
Object
ST segment elevation myocardial infarction
6. Acute myocardial infarction PROCESS_OF hospitalized patients
Subject
Acute myocardial infarction
Predicate
PROCESS_OF
Object
hospitalized patients
7. Acute myocardial infarction PROCESS_OF Patients
Subject
Acute myocardial infarction
Predicate
PROCESS_OF
Object
Patients
8. Out-of-Hospital Cardiac Arrest OCCURS_IN Patients
Subject
Out-of-Hospital Cardiac Arrest
Predicate
OCCURS_IN
Object
Patients
9. Out-of-Hospital Cardiac Arrest PROCESS_OF Patients
Subject
Out-of-Hospital Cardiac Arrest
Predicate
PROCESS_OF
Object
Patients
10. ST segment elevation myocardial infarction PROCESS_OF Ethnic group
Subject
ST segment elevation myocardial infarction
Predicate
PROCESS_OF
Object
Ethnic group
11. Coronary angiography DIAGNOSES ST segment elevation myocardial infarction
Subject
Coronary angiography
Predicate
DIAGNOSES
Object
ST segment elevation myocardial infarction
12. Acute myocardial infarction PROCESS_OF hospitalized patients
Subject
Acute myocardial infarction
Predicate
PROCESS_OF
Object
hospitalized patients
ABSTRACT
Background Studies have reported significant reduction in acute myocardial infarction-related hospitalizations during the coronavirus disease 2019 (COVID-19) pandemic. However, whether these trends are associated with increased incidence of out-of-hospital cardiac arrest (OHCA) in this population is unknown. Methods and Results Acute myocardial infarction hospitalizations with OHCA during the COVID-19 period (February 1-May 14, 2020) from the Myocardial Ischaemia National Audit Project and British Cardiovascular Intervention Society data sets were analyzed. Temporal trends were assessed using Poisson models with equivalent pre-COVID-19 period (February 1-May 14, 2019) as reference. Acute myocardial infarction hospitalizations during COVID-19 period were reduced by >50% (n=20 310 versus n=9325). OHCA was more prevalent during the COVID-19 period compared with the pre-COVID-19 period (5.6% versus 3.6%), with a 56% increase in the incidence of OHCA (incidence rate ratio, 1.56; 95% CI, 1.39-1.74). Patients experiencing OHCA during COVID-19 period were likely to be older, likely to be women, likely to be of Asian ethnicity, and more likely to present with ST-segment-elevation myocardial infarction. The overall rates of invasive coronary angiography (58.4% versus 71.6%; P<0.001) were significantly lower among the OHCA group during COVID-19 period with increased time to reperfusion (mean, 2.1 versus 1.1 hours; P=0.05) in those with ST-segment-elevation myocardial infarction. The adjusted in-hospital mortality probability increased from 27.7% in February 2020 to 35.8% in May 2020 in the COVID-19 group (P<.001). Conclusions In this national cohort of hospitalized patients with acute myocardial infarction, we observed a significant increase in incidence of OHCA during COVID-19 period paralleled with reduced access to guideline-recommended care and increased in-hospital mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Out-of-Hospital Cardiac Arrest / ST Elevation Myocardial Infarction / COVID-19 / Hospitalization Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Am Heart Assoc Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Out-of-Hospital Cardiac Arrest / ST Elevation Myocardial Infarction / COVID-19 / Hospitalization Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Am Heart Assoc Year: 2020 Document Type: Article