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Recent discoveries in HIV-1 reverse transcriptase inhibitors.
Gu, Shuang-Xi; Zhu, Yuan-Yuan; Wang, Chao; Wang, Hai-Feng; Liu, Gen-Yan; Cao, Shuang; Huang, Lu.
  • Gu SX; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China; Key Laboratory of Advanced Drug Preparation Te
  • Zhu YY; School of Chemistry & Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
  • Wang C; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
  • Wang HF; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China.
  • Liu GY; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
  • Cao S; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
  • Huang L; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
Curr Opin Pharmacol ; 54: 166-172, 2020 10.
Article in English | MEDLINE | ID: covidwho-943015
ABSTRACT
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active antiretroviral therapy (HAART), which has achieved great success in controlling AIDS epidemic in reducing drastically the morbidity and mortality of HIV-infected patients. RTIs are divided into two categories, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). In this review, the recent discoveries in NRTIs and NNRTIs, including approved anti-HIV drugs and noteworthy drug candidates in different development stages, are summarized, and their future direction is prospected.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / HIV-1 / Reverse Transcriptase Inhibitors Limits: Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / HIV-1 / Reverse Transcriptase Inhibitors Limits: Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article