Recent discoveries in HIV-1 reverse transcriptase inhibitors.
Curr Opin Pharmacol
; 54: 166-172, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-943015
ABSTRACT
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active antiretroviral therapy (HAART), which has achieved great success in controlling AIDS epidemic in reducing drastically the morbidity and mortality of HIV-infected patients. RTIs are divided into two categories, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). In this review, the recent discoveries in NRTIs and NNRTIs, including approved anti-HIV drugs and noteworthy drug candidates in different development stages, are summarized, and their future direction is prospected.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
/
Reverse Transcriptase Inhibitors
Limits:
Humans
Language:
English
Journal:
Curr Opin Pharmacol
Journal subject:
Pharmacology
Year:
2020
Document Type:
Article
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