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Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia.
Vaira, L A; Hopkins, C; Sandison, A; Manca, A; Machouchas, N; Turilli, D; Lechien, J R; Barillari, M R; Salzano, G; Cossu, A; Saussez, S; De Riu, G.
  • Vaira LA; Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Italy.
  • Hopkins C; Biomedical Science Department, University of Sassari, Italy.
  • Sandison A; Department of ENT, King's College, London, UK.
  • Manca A; Department of Histopathology, Charing Cross Hospital and Imperial College Healthcare NHS Trust, London, UK.
  • Machouchas N; Histopathology Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
  • Turilli D; Otorhinolaryngology Operative Unit, University Hospital of Sassari, Italy.
  • Lechien JR; Radiology Operative Unit, University Hospital of Sassari, Italy.
  • Barillari MR; COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies ('YO-IFOS'), Belgium.
  • Salzano G; Department of Human and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons ('UMons'), Belgium.
  • Cossu A; Department of Mental and Physical Health and Preventive Medicine, Luigi Vanvitelli University, Naples, Italy.
  • Saussez S; Maxillofacial Surgery Unit, University Hospital of Naples 'Federico II', Italy.
  • De Riu G; Histopathology Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
J Laryngol Otol ; 134(12): 1123-1127, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-943804
ABSTRACT

BACKGROUND:

Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. CASE REPORT This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2.

CONCLUSION:

The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Olfactory Mucosa / Anosmia / COVID-19 / Olfaction Disorders Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal: J Laryngol Otol Journal subject: Otolaryngology Year: 2020 Document Type: Article Affiliation country: S0022215120002455

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Olfactory Mucosa / Anosmia / COVID-19 / Olfaction Disorders Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal: J Laryngol Otol Journal subject: Otolaryngology Year: 2020 Document Type: Article Affiliation country: S0022215120002455