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Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury.
Li, Zheng; Li, Xingye; Shen, Jianxiong; Tan, Haining; Rong, Tianhua; Lin, Youxi; Feng, Erwei; Chen, Zhengguang; Jiao, Yang; Liu, Gang; Zhang, Lin; Vai Chan, Matthew Tak; Kei Wu, William Ka.
  • Li Z; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Li X; Department of Orthopedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Jishuitan Orthopaedic College of Tsinghua University, Beijing, China.
  • Shen J; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Tan H; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Rong T; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Lin Y; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Feng E; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Chen Z; Department of Radiology, Dongzhimen Hospital Beijing University of Chinese Medicine. No. 5 Hai Yun Cang, Dongcheng District, Beijing 100700, P.R. China.
  • Jiao Y; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Liu G; Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100042, China.
  • Zhang L; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
  • Vai Chan MT; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
  • Kei Wu WK; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Brief Bioinform ; 22(2): 1291-1296, 2021 03 22.
Article in English | MEDLINE | ID: covidwho-1343632
Semantic information from SemMedBD (by NLM)
1. Respiratory Tract Infections AFFECTS Patients
Subject
Respiratory Tract Infections
Predicate
AFFECTS
Object
Patients
2. Spinal Muscular Atrophy PROCESS_OF Patients
Subject
Spinal Muscular Atrophy
Predicate
PROCESS_OF
Object
Patients
3. Predisposition -- attribute ASSOCIATED_WITH Spinal Muscular Atrophy
Subject
Predisposition -- attribute
Predicate
ASSOCIATED_WITH
Object
Spinal Muscular Atrophy
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Mutation CAUSES Spinal Muscular Atrophy
Subject
Mutation
Predicate
CAUSES
Object
Spinal Muscular Atrophy
6. SMN1 gene|SMN1 AFFECTS COVID-19
Subject
SMN1 gene|SMN1
Predicate
AFFECTS
Object
COVID-19
7. Respiratory Tract Infections AFFECTS Patients
Subject
Respiratory Tract Infections
Predicate
AFFECTS
Object
Patients
8. Spinal Muscular Atrophy PROCESS_OF Patients
Subject
Spinal Muscular Atrophy
Predicate
PROCESS_OF
Object
Patients
9. Predisposition -- attribute ASSOCIATED_WITH Spinal Muscular Atrophy
Subject
Predisposition -- attribute
Predicate
ASSOCIATED_WITH
Object
Spinal Muscular Atrophy
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Mutation CAUSES Spinal Muscular Atrophy
Subject
Mutation
Predicate
CAUSES
Object
Spinal Muscular Atrophy
12. SMN1 gene|SMN1 AFFECTS COVID-19
Subject
SMN1 gene|SMN1
Predicate
AFFECTS
Object
COVID-19
ABSTRACT
Patients with spinal muscular atrophy (SMA) are susceptible to the respiratory infections and might be at a heightened risk of poor clinical outcomes upon contracting coronavirus disease 2019 (COVID-19). In the face of the COVID-19 pandemic, the potential associations of SMA with the susceptibility to and prognostication of COVID-19 need to be clarified. We documented an SMA case who contracted COVID-19 but only developed mild-to-moderate clinical and radiological manifestations of pneumonia, which were relieved by a combined antiviral and supportive treatment. We then reviewed a cohort of patients with SMA who had been living in the Hubei province since November 2019, among which the only 1 out of 56 was diagnosed with COVID-19 (1.79%, 1/56). Bioinformatic analysis was carried out to delineate the potential genetic crosstalk between SMN1 (mutation of which leads to SMA) and COVID-19/lung injury-associated pathways. Protein-protein interaction analysis by STRING suggested that loss-of-function of SMN1 might modulate COVID-19 pathogenesis through CFTR, CXCL8, TNF and ACE. Expression quantitative trait loci analysis also revealed a link between SMN1 and ACE2, despite low-confidence protein-protein interactions as suggested by STRING. This bioinformatic analysis could give hint on why SMA might not necessarily lead to poor outcomes in patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Muscular Atrophy, Spinal / Survival of Motor Neuron 1 Protein / Angiotensin-Converting Enzyme 2 / COVID-19 Subject: Muscular Atrophy, Spinal / Survival of Motor Neuron 1 Protein / Angiotensin-Converting Enzyme 2 / COVID-19 Language: English Journal: Brief Bioinform Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Muscular Atrophy, Spinal / Survival of Motor Neuron 1 Protein / Angiotensin-Converting Enzyme 2 / COVID-19 Subject: Muscular Atrophy, Spinal / Survival of Motor Neuron 1 Protein / Angiotensin-Converting Enzyme 2 / COVID-19 Language: English Journal: Brief Bioinform Year: 2021
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