Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19.
Front Immunol
; 11: 1665, 2020.
Article
in English
| MEDLINE | ID: covidwho-945649
ABSTRACT
We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Immunosuppression Therapy
/
Immunoglobulins, Intravenous
/
Adrenal Cortex Hormones
/
Coronavirus Infections
/
Lymphohistiocytosis, Hemophagocytic
/
Macrophage Activation Syndrome
/
Pandemics
/
Betacoronavirus
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
Language:
English
Journal:
Front Immunol
Year:
2020
Document Type:
Article
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