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Potential CD8+ T Cell Cross-Reactivity Against SARS-CoV-2 Conferred by Other Coronavirus Strains.
Lee, Chloe H; Pinho, Mariana Pereira; Buckley, Paul R; Woodhouse, Isaac B; Ogg, Graham; Simmons, Alison; Napolitani, Giorgio; Koohy, Hashem.
  • Lee CH; MRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
  • Pinho MP; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Buckley PR; MRC WIMM Centre For Computational Biology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
  • Woodhouse IB; MRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
  • Ogg G; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Simmons A; MRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
  • Napolitani G; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Koohy H; MRC WIMM Centre For Computational Biology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Front Immunol ; 11: 579480, 2020.
Article in English | MEDLINE | ID: covidwho-945659
Semantic information from SemMedBD (by NLM)
1. Cross Reactions PROCESS_OF CD8-Positive T-Lymphocytes
Subject
Cross Reactions
Predicate
PROCESS_OF
Object
CD8-Positive T-Lymphocytes
2. Disease AFFECTS Disease Outcome
Subject
Disease
Predicate
AFFECTS
Object
Disease Outcome
3. Predisposition -- attribute ASSOCIATED_WITH COVID-19
Subject
Predisposition -- attribute
Predicate
ASSOCIATED_WITH
Object
COVID-19
4. Epitopes PART_OF CD8-Positive T-Lymphocytes
Subject
Epitopes
Predicate
PART_OF
Object
CD8-Positive T-Lymphocytes
5. Cross Reactions PROCESS_OF T-Lymphocyte
Subject
Cross Reactions
Predicate
PROCESS_OF
Object
T-Lymphocyte
6. Epitopes PART_OF 2019 novel coronavirus
Subject
Epitopes
Predicate
PART_OF
Object
2019 novel coronavirus
7. Proteome PART_OF Homo sapiens
Subject
Proteome
Predicate
PART_OF
Object
Homo sapiens
8. Virus PROCESS_OF Family
Subject
Virus
Predicate
PROCESS_OF
Object
Family
9. Orthomyxoviridae LOCATION_OF Epitopes
Subject
Orthomyxoviridae
Predicate
LOCATION_OF
Object
Epitopes
10. Genus: Coronavirus LOCATION_OF Epitopes
Subject
Genus: Coronavirus
Predicate
LOCATION_OF
Object
Epitopes
11. Epitopes compared_with Epitopes
Subject
Epitopes
Predicate
compared_with
Object
Epitopes
12. Vaccines AFFECTS Immune response
Subject
Vaccines
Predicate
AFFECTS
Object
Immune response
13. Cross Reactions PROCESS_OF CD8-Positive T-Lymphocytes
Subject
Cross Reactions
Predicate
PROCESS_OF
Object
CD8-Positive T-Lymphocytes
14. Disease AFFECTS Disease Outcome
Subject
Disease
Predicate
AFFECTS
Object
Disease Outcome
15. Predisposition -- attribute ASSOCIATED_WITH COVID-19
Subject
Predisposition -- attribute
Predicate
ASSOCIATED_WITH
Object
COVID-19
16. Epitopes PART_OF CD8-Positive T-Lymphocytes
Subject
Epitopes
Predicate
PART_OF
Object
CD8-Positive T-Lymphocytes
17. Cross Reactions PROCESS_OF T-Lymphocyte
Subject
Cross Reactions
Predicate
PROCESS_OF
Object
T-Lymphocyte
18. Epitopes PART_OF 2019 novel coronavirus
Subject
Epitopes
Predicate
PART_OF
Object
2019 novel coronavirus
19. Proteome PART_OF Homo sapiens
Subject
Proteome
Predicate
PART_OF
Object
Homo sapiens
20. Virus PROCESS_OF Family
Subject
Virus
Predicate
PROCESS_OF
Object
Family
21. Orthomyxoviridae LOCATION_OF Epitopes
Subject
Orthomyxoviridae
Predicate
LOCATION_OF
Object
Epitopes
22. Genus: Coronavirus LOCATION_OF Epitopes
Subject
Genus: Coronavirus
Predicate
LOCATION_OF
Object
Epitopes
23. Epitopes compared_with Epitopes
Subject
Epitopes
Predicate
compared_with
Object
Epitopes
24. Vaccines AFFECTS Immune response
Subject
Vaccines
Predicate
AFFECTS
Object
Immune response
ABSTRACT
While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad range in susceptibility and severity to the disease, the pre-existing immune memory to related pathogens cross-reactive against SARS-CoV-2 can influence the disease outcome in COVID-19. Here, we investigated the potential extent of T cell cross-reactivity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be conferred by other coronaviruses and influenza virus, and generated an in silico map of public and private CD8+ T cell epitopes between coronaviruses. We observed 794 predicted SARS-CoV-2 epitopes of which 52% were private and 48% were public. Ninety-nine percent of the public epitopes were shared with SARS-CoV and 5.4% were shared with either one of four common coronaviruses, 229E, HKU1, NL63, and OC43. Moreover, to assess the potential risk of self-reactivity and/or diminished T cell response for peptides identical or highly similar to the host, we identified predicted epitopes with high sequence similarity with human proteome. Lastly, we compared predicted epitopes from coronaviruses with epitopes from influenza virus deposited in IEDB, and found only a small number of peptides with limited potential for cross-reactivity between the two virus families. We believe our comprehensive in silico profile of private and public epitopes across coronaviruses would facilitate design of vaccines, and provide insights into the presence of pre-existing coronavirus-specific memory CD8+ T cells that may influence immune responses against SARS-CoV-2.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus / CD8-Positive T-Lymphocytes / Cross Reactions / SARS-CoV-2 Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.579480

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus / CD8-Positive T-Lymphocytes / Cross Reactions / SARS-CoV-2 Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.579480