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Alkaloids: Therapeutic Potential against Human Coronaviruses.
Fielding, Burtram C; da Silva Maia Bezerra Filho, Carlos; Ismail, Nasser S M; Sousa, Damião Pergentino de.
  • Fielding BC; Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, University of the Western Cape, Bellville 7535, South Africa.
  • da Silva Maia Bezerra Filho C; Department of Pharmaceutical Sciences, Federal University of Paraíba, Paraíba 58051-900, Brazil.
  • Ismail NSM; Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 12311, Egypt.
  • Sousa DP; Department of Pharmaceutical Sciences, Federal University of Paraíba, Paraíba 58051-900, Brazil.
Molecules ; 25(23)2020 Nov 24.
Article in English | MEDLINE | ID: covidwho-945886
ABSTRACT
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Alkaloids / Spike Glycoprotein, Coronavirus / COVID-19 Drug Treatment Limits: Humans Language: English Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Molecules25235496

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Alkaloids / Spike Glycoprotein, Coronavirus / COVID-19 Drug Treatment Limits: Humans Language: English Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Molecules25235496