Zinc and SARSCoV2: A molecular modeling study of Zn interactions with RNAdependent RNApolymerase and 3Clike proteinase enzymes.
Int J Mol Med
; 47(1): 326-334, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-945986
ABSTRACT
RNAdependent RNApolymerase (RdRp) and 3Clike proteinase (3CLpro) are two main enzymes that play a key role in the replication of SARSCoV2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in viral infection control. Thus, the present study models potential Zn binding to RdRp and the 3CLpro. Through molecular modeling, the Zn binding sites in the aforementioned two important enzymes of viral replication were found to be conserved between severe acute respiratory syndrome (SARS)coronavirus (CoV) and SARSCoV2. The location of these sites may influence the enzymatic activity of 3CLpro and RdRp in coronavirus disease 2019 (COVID19). Since Zn has established immune health benefits, is readily available, nonexpensive and a safe food supplement, with the comparisons presented here between SARSCoV and COVID19, the present study proposes that Zn could help ameliorate the disease process of COVID19 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Zinc
/
Models, Molecular
/
Coronavirus RNA-Dependent RNA Polymerase
/
Coronavirus 3C Proteases
/
SARS-CoV-2
Type of study:
Prognostic study
Language:
English
Journal:
Int J Mol Med
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2021
Document Type:
Article
Affiliation country:
Ijmm.2020.4790
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