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Impact of COVID-19 on the thyroid gland: an update.
Scappaticcio, Lorenzo; Pitoia, Fabián; Esposito, Katherine; Piccardo, Arnoldo; Trimboli, Pierpaolo.
  • Scappaticcio L; Division of Endocrinology and Metabolic Diseases, University Hospital "Luigi Vanvitelli", University of Campania "L. Vanvitelli", Naples, Italy.
  • Pitoia F; Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
  • Esposito K; Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.
  • Piccardo A; Diabetes Unit, University Hospital "Luigi Vanvitelli", University of Campania "L. Vanvitelli", Naples, Italy.
  • Trimboli P; Department of Nuclear Medicine, Galliera Hospital, Genoa, Italy.
Rev Endocr Metab Disord ; 22(4): 803-815, 2021 12.
Article in English | MEDLINE | ID: covidwho-947048
ABSTRACT
Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. SARS-CoV-2 uses ACE2 combined with the transmembrane protease serine 2 (TMPRSS2) as the key molecular complex to infect the host cells. Interestingly, ACE2 and TMPRSS2 expression levels are high in the thyroid gland and more than in the lungs. Our literature search provided greater evidence that the thyroid gland and the entire hypothalamic-pituitary-thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2. Specifically, COVID-19-related thyroid disorders include thyrotoxicosis, hypothyroidism, as well as nonthyroidal illness syndrome. Moreover, we noticed that treatment plans for thyroid cancer are considerably changing in the direction of more teleconsultations and less diagnostic and therapeutical procedures. The current review includes findings that could be changed soon by new results on the topic, considering the rapidity of worldwide research on COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thyroid Diseases / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Rev Endocr Metab Disord Journal subject: Endocrinology / Metabolism Year: 2021 Document Type: Article Affiliation country: S11154-020-09615-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thyroid Diseases / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Rev Endocr Metab Disord Journal subject: Endocrinology / Metabolism Year: 2021 Document Type: Article Affiliation country: S11154-020-09615-z