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Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?
Verkhratsky, Alexei; Li, Qing; Melino, Sonia; Melino, Gerry; Shi, Yufang.
  • Verkhratsky A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
  • Li Q; Achucarro Center for Neuroscience, IKERBASQUE, 48011, Bilbao, Spain. Alexej.Verkhratsky@manchester.ac.uk.
  • Melino S; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
  • Melino G; University of Rome Tor Vergata, via Cracovia 1, 00133, Rome, Italy.
  • Shi Y; University of Rome Tor Vergata, via Cracovia 1, 00133, Rome, Italy.
Biol Direct ; 15(1): 28, 2020 11 27.
Article in English | MEDLINE | ID: covidwho-947943
ABSTRACT
The pandemic of Coronavirus Disease 2019 (COVID-19) presents the world with the medical challenge associated with multifactorial nature of this pathology. Indeed COVID-19 affects several organs and systems and presents diversified clinical picture. COVID-19 affects the brain in many ways including direct infection of neural cells with SARS-CoV-2, severe systemic inflammation which floods the brain with pro-inflammatory agents thus damaging nervous cells, global brain ischaemia linked to a respiratory failure, thromboembolic strokes related to increased intravascular clotting and severe psychological stress. Often the COVID-19 is manifested by neurological and neuropsychiatric symptoms that include dizziness, disturbed sleep, cognitive deficits, delirium, hallucinations and depression. All these indicate the damage to the nervous tissue which may substantially increase the incidence of neurodegenerative diseases and promote dementia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Comorbidity / Neurodegenerative Diseases / Epidemics / Pandemics / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Biol Direct Year: 2020 Document Type: Article Affiliation country: S13062-020-00282-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Comorbidity / Neurodegenerative Diseases / Epidemics / Pandemics / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Biol Direct Year: 2020 Document Type: Article Affiliation country: S13062-020-00282-3