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COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
de Barros Viana, Milena; Rosário, Bárbara Dos Anjos; de Fátima Santana de Nazaré, Maria; Estadella, Débora; Ribeiro, Daniel Araki; Socorro de Barros Viana, Glauce.
  • de Barros Viana M; Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos11015-020, São Paulo, Brazil.
  • Rosário BDA; Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos11015-020, São Paulo, Brazil.
  • de Fátima Santana de Nazaré M; Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos11015-020, São Paulo, Brazil.
  • Estadella D; Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos11015-020, São Paulo, Brazil.
  • Ribeiro DA; Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos11015-020, São Paulo, Brazil.
  • Socorro de Barros Viana G; Department of Physiology and Pharmacology, Federal University of Ceará (UFC), Fortaleza60430-275, Ceará, Brazil.
Rev Neurosci ; 32(2): 235-247, 2021 02 23.
Article in English | MEDLINE | ID: covidwho-947988
ABSTRACT
The coronavirus disease (COVID-19), identified in Wuhan, China, on December 2019, was declared a pandemic by the World Health Organization, on March, 2020. Since then, efforts have been gathered to describe its clinical course and to determine preventive measures and treatment strategies. Adults older than 65 years of age are more susceptible to serious clinical symptoms and present higher mortality rates. Angiotensin-converting enzyme 2 (ACE2) is a major receptor for some coronavirus infection, including SARS-COV-2, but is also a crucial determinant in anti-inflammation processes during the renin-angiotensin system (RAS) functioning - converting angiotensin II to angiotensin 1-7. The decline in ACE2 expression that occurs with aging has been associated to the higher morbidity and mortality rates in older adults. These observations highlight the importance of investigating the association between COVID-19 and age-related neurodegenerative disorders, i.e., Parkinson's and Alzheimer's diseases. A possible option to reduce the risk of COVID-19 is vitamin D supplementation, due to its anti-inflammatory and immune-system-modulating effects. It has also been suggested that vitamin D supplementation plays a role in slowing progression of Parkinson and Alzheimer. The present study is a literature review of articles published on the theme COVID-19, Parkinson and Alzheimer's diseases, and the role played by vitamin D. PUBMED, MEDLINE, and EMBASE databases were consulted. Results confirm neurodegenerative and neuroinflammatory effects of COVID-19, aggravated in Parkinson's and Alzheimer's patients, and the important role of vitamin D as a possible therapeutic strategy. Nevertheless, randomized controlled trials and large population studies are still warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cholecalciferol / Neurodegenerative Diseases / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0074

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cholecalciferol / Neurodegenerative Diseases / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0074