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An integrative analysis identifying transcriptional features and key genes involved in COVID-19.
Li, Guoping; Wang, Junyi; He, Xiang; Zhang, Lei; Ran, Qin; Xiong, Anying; Wu, Dehong; Hu, Lingjuan; Song, Qi; Zhu, Dong.
  • Li G; Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
  • Wang J; Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
  • He X; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Taipa, Macau (SAR), China.
  • Zhang L; Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
  • Ran Q; Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
  • Xiong A; Department of Respiratory Disease, Sichuan Friendship Hospital, Chengdu 610000, China.
  • Wu D; Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
  • Hu L; Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
  • Song Q; Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
  • Zhu D; Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.
Epigenomics ; 12(22): 1969-1981, 2020 11.
Article in English | MEDLINE | ID: covidwho-948022
ABSTRACT

Aim:

To elucidate the transcriptional characteristics of COVID-19. Materials &

methods:

We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells.

Results:

Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified LCN2, STAT1 and UBE2L6 as core genes during SARS-CoV-2 infection.

Conclusion:

The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ubiquitin-Conjugating Enzymes / STAT1 Transcription Factor / Lipocalin-2 / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Epigenomics Year: 2020 Document Type: Article Affiliation country: Epi-2020-0168

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ubiquitin-Conjugating Enzymes / STAT1 Transcription Factor / Lipocalin-2 / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Epigenomics Year: 2020 Document Type: Article Affiliation country: Epi-2020-0168