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Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.
Ragia, Georgia; Manolopoulos, Vangelis G.
  • Ragia G; Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, 68100, Greece.
  • Manolopoulos VG; Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, 68100, Greece.
Pharmacogenomics ; 21(18): 1311-1329, 2020 12.
Article in English | MEDLINE | ID: covidwho-948025
ABSTRACT
There is considerable variation in disease course among individuals infected with SARS-CoV-2. Many of them do not exhibit any symptoms, while some others proceed to develop COVID-19; however, severity of COVID-19 symptoms greatly differs among individuals. Focusing on the early events related to SARS-CoV-2 entry to cells through the ACE2 pathway, we describe how variability in (epi)genetic factors can conceivably explain variability in disease course. We specifically focus on variations in ACE2, TMPRSS2 and FURIN genes, as central components for SARS-CoV-2 infection, and on other molecules that modulate their expression such as CALM, ADAM-17, AR and ESRs. We propose a genetic classifier for predicting SARS-CoV-2 infectivity potential as a preliminary tool for identifying the at-risk-population. This tool can serve as a dynamic scaffold being updated and adapted to validated (epi)genetic data. Overall, the proposed approach holds potential for better personalization of COVID-19 handling.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Furin / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Pharmacogenomics Journal subject: Pharmacology / Genetics, Medical Year: 2020 Document Type: Article Affiliation country: Pgs-2020-0092

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Furin / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Pharmacogenomics Journal subject: Pharmacology / Genetics, Medical Year: 2020 Document Type: Article Affiliation country: Pgs-2020-0092