Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination.
Nanomedicine (Lond)
; 15(29): 2883-2894, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-949049
ABSTRACT
The discovery of stimulator of interferon genes (STING) and their agonists as primary components that link antiviral innate and adaptive immunity has motivated growing research on STING agonist-mediated immunotherapy and vaccine development. To overcome the delivery challenge in shuttling highly polar STING agonists, typically in the form of cyclic dinucleotides, to target cells and to STING proteins in cellular cytosol, numerous nanoformulation strategies have been implemented for effective STING activation. While many STING-activating nanoparticles are developed to enhance anticancer immunotherapy, their adoption as vaccine adjuvant has vastly propelled antiviral vaccination efforts against challenging public health threats, including HIV, influenza and coronaviruses. In light of the COVID-19 pandemic that has thrusted vaccine development into the public spotlight, this review highlights advances in nanomedicinal STING agonist delivery with an emphasis on their applications in antiviral vaccination.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pandemics
/
COVID-19 Vaccines
/
COVID-19 Drug Treatment
/
Immunity, Innate
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Nanomedicine (Lond)
Year:
2020
Document Type:
Article
Affiliation country:
Nnm-2020-0269
Similar
MEDLINE
...
LILACS
LIS