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The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions.
Yaribeygi, Habib; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein.
  • Yaribeygi H; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
  • Sathyapalan T; Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, UK.
  • Jamialahmadi T; Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.
  • Sahebkar A; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Diabetes Res ; 2020: 5436832, 2020.
Article in English | MEDLINE | ID: covidwho-949234
ABSTRACT
The ongoing pandemic of COVID-19 is now the major issue in global health. Evidence implies that patients with diabetes are at a higher risk of severe disease or death due to COVID-19 than individuals without diabetes. However, the underlying mechanism for this differential effect in individuals with and without diabetes is not clearly understood. We have reviewed the pathophysiological pathways which may facilitate the entry of virus or an increase in its infectivity in host cells in the diabetic milieu. We suggest that the preexisting pathological pathways in patients with poorly controlled diabetes increase the risk of infectivity and are responsible for the higher levels of tissue injury and death in patients with diabetes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Diabetes Res Year: 2020 Document Type: Article Affiliation country: 2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Diabetes Res Year: 2020 Document Type: Article Affiliation country: 2020