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Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell Carcinoma.
Kim, Kihun; Ko, Yeji; Ko, Dai Sik; Kim, Yun Hak.
  • Kim K; Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital, Republic of Korea.
  • Ko Y; Department of Statistics, University of Michigan, Michigan, USA.
  • Ko DS; Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Republic of Korea.
  • Kim YH; Department of Biomedical Informatics, School of Medicine, Pusan National University, Republic of Korea.
Biomed Res Int ; 2020: 2054376, 2020.
Article in English | MEDLINE | ID: covidwho-949235
ABSTRACT

PURPOSE:

Owing to its worldwide spread, the coronavirus disease (COVID-19) epidemic was declared a pandemic by the World Health Organization on March 11, 2020. Angiotensin-converting enzyme 2 (ACE2) is the outer surface protein of the cell membrane that is abundantly distributed in the heart, lungs, and kidneys and plays an important role in molecular docking of the severe acute respiratory syndrome coronavirus 2. In this study, we aimed to analyze the difference in the survival rate according to ACE2 expressions in pan-cancer. MATERIALS AND

METHODS:

We downloaded clinical and genomic data from The Cancer Genome Atlas. We used Kaplan-Meier with a log-rank test, and the Cox proportional hazards regression to analyze prognostic significance.

RESULTS:

In the Kaplan-Meier curve, clear cell renal cell carcinoma (ccRCC), uveal melanoma, and prostate adenocarcinoma showed statistical significance. In the Cox regression, thyroid carcinoma and glioblastoma multiforme and ccRCC showed significant results. Only ccRCC had statistical significance, and high ACE2 expression is related to good prognosis. It is known that the ACE inhibitor, a primary antihypertensive agent, increases ACE2 expression.

CONCLUSION:

Based on these results, we believe that the ACE inhibitor will be important to increase the lifespan of ccRCC patients. This study is the first research to offer a recommendation on the use of anti-hypertensive drugs to ccRCC patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / COVID-19 Drug Treatment / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Biomed Res Int Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / COVID-19 Drug Treatment / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Biomed Res Int Year: 2020 Document Type: Article