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Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell Carcinoma.
Kim, Kihun; Ko, Yeji; Ko, Dai Sik; Kim, Yun Hak.
  • Kim K; Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital, Republic of Korea.
  • Ko Y; Department of Statistics, University of Michigan, Michigan, USA.
  • Ko DS; Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Republic of Korea.
  • Kim YH; Department of Biomedical Informatics, School of Medicine, Pusan National University, Republic of Korea.
Biomed Res Int ; 2020: 2054376, 2020.
Article in English | MEDLINE | ID: covidwho-949235
Semantic information from SemMedBD (by NLM)
1. angiotensin converting enzyme 2 ASSOCIATED_WITH Renal Cell Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Renal Cell Carcinoma
2. Membrane Proteins PART_OF Plasma membrane
Subject
Membrane Proteins
Predicate
PART_OF
Object
Plasma membrane
3. Heart LOCATION_OF Membrane Proteins
Subject
Heart
Predicate
LOCATION_OF
Object
Membrane Proteins
4. Kidney LOCATION_OF Membrane Proteins
Subject
Kidney
Predicate
LOCATION_OF
Object
Membrane Proteins
5. Lung LOCATION_OF Membrane Proteins
Subject
Lung
Predicate
LOCATION_OF
Object
Membrane Proteins
6. angiotensin converting enzyme 2 ASSOCIATED_WITH Malignant Neoplasms
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Malignant Neoplasms
7. Laboratory Procedures USES TNFRSF11A protei
Subject
Laboratory Procedures
Predicate
USES
Object
TNFRSF11A protei
8. Prostate LOCATION_OF Adenocarcinoma
Subject
Prostate
Predicate
LOCATION_OF
Object
Adenocarcinoma
9. Cells LOCATION_OF Carcinoma
Subject
Cells
Predicate
LOCATION_OF
Object
Carcinoma
10. Antihypertensive Agents STIMULATES angiotensin converting enzyme 2
Subject
Antihypertensive Agents
Predicate
STIMULATES
Object
angiotensin converting enzyme 2
11. angiotensin converting enzyme 2 ASSOCIATED_WITH Renal Cell Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Renal Cell Carcinoma
12. Membrane Proteins PART_OF Plasma membrane
Subject
Membrane Proteins
Predicate
PART_OF
Object
Plasma membrane
13. Heart LOCATION_OF Membrane Proteins
Subject
Heart
Predicate
LOCATION_OF
Object
Membrane Proteins
14. Kidney LOCATION_OF Membrane Proteins
Subject
Kidney
Predicate
LOCATION_OF
Object
Membrane Proteins
15. Lung LOCATION_OF Membrane Proteins
Subject
Lung
Predicate
LOCATION_OF
Object
Membrane Proteins
16. angiotensin converting enzyme 2 ASSOCIATED_WITH Malignant Neoplasms
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Malignant Neoplasms
17. Laboratory Procedures USES TNFRSF11A protein, human|TNFRSF11A
Subject
Laboratory Procedures
Predicate
USES
Object
TNFRSF11A protein, human|TNFRSF11A
18. Prostate LOCATION_OF Adenocarcinoma
Subject
Prostate
Predicate
LOCATION_OF
Object
Adenocarcinoma
19. Cells LOCATION_OF Carcinoma
Subject
Cells
Predicate
LOCATION_OF
Object
Carcinoma
20. Antihypertensive Agents STIMULATES angiotensin converting enzyme 2
Subject
Antihypertensive Agents
Predicate
STIMULATES
Object
angiotensin converting enzyme 2
ABSTRACT

Purpose:

Owing to its worldwide spread, the coronavirus disease (COVID-19) epidemic was declared a pandemic by the World Health Organization on March 11, 2020. Angiotensin-converting enzyme 2 (ACE2) is the outer surface protein of the cell membrane that is abundantly distributed in the heart, lungs, and kidneys and plays an important role in molecular docking of the severe acute respiratory syndrome coronavirus 2. In this study, we aimed to analyze the difference in the survival rate according to ACE2 expressions in pan-cancer. Materials and

Methods:

We downloaded clinical and genomic data from The Cancer Genome Atlas. We used Kaplan-Meier with a log-rank test, and the Cox proportional hazards regression to analyze prognostic significance.

Results:

In the Kaplan-Meier curve, clear cell renal cell carcinoma (ccRCC), uveal melanoma, and prostate adenocarcinoma showed statistical significance. In the Cox regression, thyroid carcinoma and glioblastoma multiforme and ccRCC showed significant results. Only ccRCC had statistical significance, and high ACE2 expression is related to good prognosis. It is known that the ACE inhibitor, a primary antihypertensive agent, increases ACE2 expression.

Conclusion:

Based on these results, we believe that the ACE inhibitor will be important to increase the lifespan of ccRCC patients. This study is the first research to offer a recommendation on the use of anti-hypertensive drugs to ccRCC patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Type of study: Prognostic study Language: English Journal: Biomed Res Int Clinical aspect: Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Subject: Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Angiotensin-Converting Enzyme 2 / COVID-19 / Kidney Neoplasms / Neoplasm Proteins / Antihypertensive Agents Type of study: Prognostic study Language: English Journal: Biomed Res Int Clinical aspect: Prognosis Year: 2020
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