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Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients.
Marcos-Jiménez, Ana; Sánchez-Alonso, Santiago; Alcaraz-Serna, Ana; Esparcia, Laura; López-Sanz, Celia; Sampedro-Núñez, Miguel; Mateu-Albero, Tamara; Sánchez-Cerrillo, Ildefonso; Martínez-Fleta, Pedro; Gabrie, Ligia; Del Campo Guerola, Luciana; Rodríguez-Frade, José Miguel; Casasnovas, José M; Reyburn, Hugh T; Valés-Gómez, Mar; López-Trascasa, Margarita; Martín-Gayo, Enrique; Calzada, María José; Castañeda, Santos; de la Fuente, Hortensia; González-Álvaro, Isidoro; Sánchez-Madrid, Francisco; Muñoz-Calleja, Cecilia; Alfranca, Arantzazu.
  • Marcos-Jiménez A; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Sánchez-Alonso S; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Alcaraz-Serna A; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Esparcia L; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • López-Sanz C; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Sampedro-Núñez M; Department of Endocrinology, La Princesa Hospital, Madrid, Spain.
  • Mateu-Albero T; School of Medicine, Department of Medicine, Universidad Autónoma of Madrid, Madrid, Spain.
  • Sánchez-Cerrillo I; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Martínez-Fleta P; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Gabrie L; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Del Campo Guerola L; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Rodríguez-Frade JM; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Casasnovas JM; CSIC, Centro Nacional de Biotecnología, Madrid, Spain.
  • Reyburn HT; CSIC, Centro Nacional de Biotecnología, Madrid, Spain.
  • Valés-Gómez M; CSIC, Centro Nacional de Biotecnología, Madrid, Spain.
  • López-Trascasa M; CSIC, Centro Nacional de Biotecnología, Madrid, Spain.
  • Martín-Gayo E; School of Medicine, Department of Medicine, Universidad Autónoma of Madrid, Madrid, Spain.
  • Calzada MJ; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Castañeda S; School of Medicine, Department of Medicine, Universidad Autónoma of Madrid, Madrid, Spain.
  • de la Fuente H; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • González-Álvaro I; School of Medicine, Department of Medicine, Universidad Autónoma of Madrid, Madrid, Spain.
  • Sánchez-Madrid F; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Muñoz-Calleja C; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
  • Alfranca A; Department of Immunology, Biomedical Research Institute La Princesa Hospital (IIS-IP), Madrid, Spain.
Eur J Immunol ; 51(3): 634-647, 2021 03.
Article in English | MEDLINE | ID: covidwho-950362
ABSTRACT
SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients were associated with the severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B, and NK cells is associated with severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56- CD16+ NK-cells increased. Regarding humoral immunity, levels of IgM, IgA, and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless of their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes, and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID-19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulins / B-Lymphocytes / Killer Cells, Natural / T-Lymphocytes, Helper-Inducer / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048858

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulins / B-Lymphocytes / Killer Cells, Natural / T-Lymphocytes, Helper-Inducer / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048858