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Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility.
Trecarichi, Enrico Maria; Mazzitelli, Maria; Serapide, Francesca; Pelle, Maria Chiara; Tassone, Bruno; Arrighi, Eugenio; Perri, Graziella; Fusco, Paolo; Scaglione, Vincenzo; Davoli, Chiara; Lionello, Rosaria; La Gamba, Valentina; Marrazzo, Giuseppina; Busceti, Maria Teresa; Giudice, Amerigo; Ricchio, Marco; Cancelliere, Anna; Lio, Elena; Procopio, Giada; Costanzo, Francesco Saverio; Foti, Daniela Patrizia; Matera, Giovanni; Torti, Carlo.
  • Trecarichi EM; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. em.trecarichi@unicz.it.
  • Mazzitelli M; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Serapide F; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Pelle MC; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Tassone B; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Arrighi E; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Perri G; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Fusco P; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Scaglione V; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Davoli C; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Lionello R; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • La Gamba V; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Marrazzo G; Respiratory Unit, "Mater Domini" Teaching Hospital, Catanzaro, Italy.
  • Busceti MT; Respiratory Unit, "Mater Domini" Teaching Hospital, Catanzaro, Italy.
  • Giudice A; Department of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
  • Ricchio M; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Cancelliere A; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Lio E; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Procopio G; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
  • Costanzo FS; Department of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
  • Foti DP; Center of Interdepartmental Services (CIS), "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
  • Matera G; Clinical Pathology Unit, Department of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
  • Torti C; Department of Health Sciences, Institute of Microbiology, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Sci Rep ; 10(1): 20834, 2020 11 30.
Article in English | MEDLINE | ID: covidwho-1060282
ABSTRACT
Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were hypernatremia (HR 9.12), lymphocyte count < 1000 cells/µL (HR 7.45), cardiovascular diseases other than hypertension (HR 6.41), and higher levels of serum interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly patients with COVID-19 and hypernatremia, lymphopenia, CVD other than hypertension, and higher IL-6 serum levels were identified as independent predictors of in-hospital mortality. Given the small population size as major limitation of our study, further investigations are necessary to better understand and confirm our findings in elderly patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Long-Term Care / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-77641-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Long-Term Care / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-77641-7