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ELISA detection of SARS-CoV-2 antibodies in saliva.
MacMullan, Melanie A; Ibrayeva, Albina; Trettner, Kylie; Deming, Laura; Das, Sudipta; Tran, Frances; Moreno, Jose Ricardo; Casian, Joseph G; Chellamuthu, Prithivi; Kraft, Jeffrey; Kozak, Kenneth; Turner, Fred E; Slepnev, Vladimir I; Le Page, Lydia M.
  • MacMullan MA; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Ibrayeva A; Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, USA.
  • Trettner K; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Deming L; Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, W.M. Keck School of Medicine, Los Angeles, USA.
  • Das S; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
  • Tran F; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Moreno JR; Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, USA.
  • Casian JG; Bridge Institute, Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, USA.
  • Chellamuthu P; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Kraft J; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Kozak K; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Turner FE; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
  • Slepnev VI; Bridge Institute, Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, USA.
  • Le Page LM; Curative Inc, 430 S Cataract Ave, San Dimas, CA, 91773, USA.
Sci Rep ; 10(1): 20818, 2020 11 30.
Article in English | MEDLINE | ID: covidwho-951690
Preprint
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ABSTRACT
To facilitate containment of the COVID-19 pandemic currently active in the United States and across the world, options for easy, non-invasive antibody testing are required. Here we have adapted a commercially available, serum-based enzyme-linked immunosorbent assay (ELISA) for use with saliva samples, achieving 84.2% sensitivity and 100% specificity in a set of 149 clinical samples. This strategy will enable widespread, affordable testing for patients who experienced this disease, whilst minimizing exposure risk for healthcare workers.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Enzyme-Linked Immunosorbent Assay / COVID-19 Serological Testing / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-77555-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Enzyme-Linked Immunosorbent Assay / COVID-19 Serological Testing / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-77555-4