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Thrombocytopenia and thrombosis in hospitalized patients with COVID-19.
Mei, Heng; Luo, Lili; Hu, Yu.
  • Mei H; Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
  • Luo L; Hubei Clinical and Research Centre of Thrombosis and Hemostasis, Wuhan, China.
  • Hu Y; Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
J Hematol Oncol ; 13(1): 161, 2020 12 01.
Article in English | MEDLINE | ID: covidwho-953805
ABSTRACT
As our understanding on coronavirus disease 2019 (COVID-19) deepens, it is increasingly recognized that COVID-19 is more than a respiratory condition. Thrombocytopenia and thromboembolic complications are a composite factor associated with critical COVID-19 and increased mortality. Immune-inflammation-mediated destruction, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection per se and increased consumption are proposed to be responsible for thrombocytopenia. Multiple concomitant conditions or results caused by SARS-CoV-2 infection are high risk factors for thrombosis. Recently, platelet activation and platelet-mediated immune inflammation induced by SARS-CoV-2 infection were also found to be the contributors to the thrombosis in COVID-19 patients. In addition to thrombus scoring system, D-dimer is an excellent indicator for monitoring thrombosis. COVID-19 patients with high risk for thrombosis should be subjected to early thromboprophylaxis, and prolonged activated partial-thromboplastin time should not be a barrier to the use of anticoagulation therapies in the control of thrombosis in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Thrombosis / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Hematol Oncol Journal subject: Hematology / Neoplasms Year: 2020 Document Type: Article Affiliation country: S13045-020-01003-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Thrombosis / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Hematol Oncol Journal subject: Hematology / Neoplasms Year: 2020 Document Type: Article Affiliation country: S13045-020-01003-z