Venovenous ECMO treatment, outcomes, and complications in adults according to large case series: A systematic review.
Int J Artif Organs
; 44(7): 481-488, 2021 Jul.
Article
in English
| MEDLINE | ID: covidwho-954071
ABSTRACT
BACKGROUND:
Venovenous extracorporeal membrane oxygenation (VV ECMO) has gained popularity for the treatment of refractory respiratory failure during and after the 2009 influenza pandemic, and still represents a precious therapeutic resource for severe novel coronavirus 2019 infection. However, most of the published studies are small case series, and only two randomized trials exist in literature.AIM:
Aim of this systematic review is to describe trends in VV ECMO treatment outcomes according to large studies only.METHODS:
We searched and included studies with more than 100 VV ECMO cases dated up to August 1st, 2019.RESULTS:
Thirty-three studies published in the period 2011-2019 met inclusion criteria, for a total of 12,860 patients (age 46.3 ± 17.4 years). ARDS was mainly by pneumonia, in 3126 (37%) cases; further 401(7%) patients had H1N1 Influenza A infection. Cannulation-related complications occurred in 502 (7%) cases. Weighted mean (95% confidence interval) of VV ECMO duration was 8.9 (8.7-9.1) days, and ICU stay was 23.6 (22.4-24.8) days. Mortality at the longest follow up available was 40%. Data collection in 70% of the studies had a duration of >5 years.CONCLUSION:
This study reveals the characteristics of large case VV ECMO studies.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Extracorporeal Membrane Oxygenation
/
Influenza A Virus, H1N1 Subtype
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adult
/
Humans
/
Middle aged
Language:
English
Journal:
Int J Artif Organs
Year:
2021
Document Type:
Article
Affiliation country:
0391398820975408
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