Your browser doesn't support javascript.
Non-Coding RNAs and SARS-Related Coronaviruses.
Henzinger, Hanna; Barth, Dominik A; Klec, Christiane; Pichler, Martin.
  • Henzinger H; Comprehensive Cancer Center Graz, Research Unit of Non-Coding RNAs and Genome Editing, Department of Internal Medicine, Division of Clinical Oncology, Medical University of Graz, 8036 Graz, Austria.
  • Barth DA; Comprehensive Cancer Center Graz, Research Unit of Non-Coding RNAs and Genome Editing, Department of Internal Medicine, Division of Clinical Oncology, Medical University of Graz, 8036 Graz, Austria.
  • Klec C; Comprehensive Cancer Center Graz, Research Unit of Non-Coding RNAs and Genome Editing, Department of Internal Medicine, Division of Clinical Oncology, Medical University of Graz, 8036 Graz, Austria.
  • Pichler M; Comprehensive Cancer Center Graz, Research Unit of Non-Coding RNAs and Genome Editing, Department of Internal Medicine, Division of Clinical Oncology, Medical University of Graz, 8036 Graz, Austria.
Viruses ; 12(12)2020 12 01.
Article in English | MEDLINE | ID: covidwho-954243
Semantic information from SemMedBD (by NLM)
1. RN AFFECTS C1817908
Subject
RN
Predicate
AFFECTS
Object
C1817908
2. MicroRNAs CAUSES silence
Subject
MicroRNAs
Predicate
CAUSES
Object
silence
3. DNA Sequence INHIBITS Viral Proteins
Subject
DNA Sequence
Predicate
INHIBITS
Object
Viral Proteins
4. MicroRNAs PART_OF Homo sapiens
Subject
MicroRNAs
Predicate
PART_OF
Object
Homo sapiens
5. Mutation AFFECTS Pathogenicity
Subject
Mutation
Predicate
AFFECTS
Object
Pathogenicity
6. Viral Genome LOCATION_OF Mutation
Subject
Viral Genome
Predicate
LOCATION_OF
Object
Mutation
7. Immune response AFFECTS Predisposition -- attribute
Subject
Immune response
Predicate
AFFECTS
Object
Predisposition -- attribute
8. MicroRNAs INTERACTS_WITH Receptor
Subject
MicroRNAs
Predicate
INTERACTS_WITH
Object
Receptor
9. RN AUGMENTS C5203670
Subject
RN
Predicate
AUGMENTS
Object
C5203670
10. RNA, Untranslated AFFECTS Cellular Immune Response
Subject
RNA, Untranslated
Predicate
AFFECTS
Object
Cellular Immune Response
11. MicroRNAs CAUSES silence
Subject
MicroRNAs
Predicate
CAUSES
Object
silence
12. DNA Sequence INHIBITS Viral Proteins
Subject
DNA Sequence
Predicate
INHIBITS
Object
Viral Proteins
13. MicroRNAs PART_OF Homo sapiens
Subject
MicroRNAs
Predicate
PART_OF
Object
Homo sapiens
14. Mutation AFFECTS Pathogenicity
Subject
Mutation
Predicate
AFFECTS
Object
Pathogenicity
15. Viral Genome LOCATION_OF Mutation
Subject
Viral Genome
Predicate
LOCATION_OF
Object
Mutation
16. Immune response AFFECTS Predisposition -- attribute
Subject
Immune response
Predicate
AFFECTS
Object
Predisposition -- attribute
17. MicroRNAs INTERACTS_WITH Receptors, Cell Surface
Subject
MicroRNAs
Predicate
INTERACTS_WITH
Object
Receptors, Cell Surface
18. RNA, Untranslated AUGMENTS COVID-19
Subject
RNA, Untranslated
Predicate
AUGMENTS
Object
COVID-19
ABSTRACT
The emergence of SARS-CoV-2 in 2019 has caused a major health and economic crisis around the globe. Gaining knowledge about its attributes and interactions with human host cells is crucial. Non-coding RNAs (ncRNAs) are involved in the host cells' innate antiviral immune response. In RNA interference, microRNAs (miRNAs) may bind to complementary sequences of the viral RNA strand, forming an miRNA-induced silencing complex, which destroys the viral RNA, thereby inhibiting viral protein expression. There are several targets for human miRNAs on SARS-CoV-2's RNA, most of which are in the 5' and 3' untranslated regions. Mutations of the viral genome causing the creation or loss of miRNA binding sites may have crucial effects on SARS-CoV-2 pathogenicity. In addition to mediating immunity, the ncRNA landscape of host cells further influences their susceptibility to virus infection, as certain miRNAs are essential in the regulation of cellular receptors that are necessary for virus invasion. Conversely, virus infection also changes the host ncRNA expression patterns, possibly augmenting conditions for viral replication and dissemination. Hence, ncRNAs typically upregulated in SARS-CoV-2 infection could be useful biomarkers for disease progression and severity. Understanding these mechanisms could provide further insight into the pathogenesis and possible treatment options against COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / RNA, Untranslated Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12121374

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / RNA, Untranslated Type of study: Prognostic study Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: V12121374