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Interleukin-6 signaling blockade treatment for cytokine release syndrome in COVID-19 (Review).
Chen, Jia-Jie; Zhang, Li-Na; Hou, Hu; Xu, Lingqing; Ji, Kunmei.
  • Chen JJ; Department of Biochemistry and Molecular Biology, Health Science Center of Shenzhen University, Shenzhen, Guangdong 518060, P.R. China.
  • Zhang LN; Department of Biochemistry and Molecular Biology, Health Science Center of Shenzhen University, Shenzhen, Guangdong 518060, P.R. China.
  • Hou H; Department of Clinical Laboratory, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.
  • Xu L; Department of Clinical Laboratory, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong 511518, P.R. China.
  • Ji K; Department of Biochemistry and Molecular Biology, Health Science Center of Shenzhen University, Shenzhen, Guangdong 518060, P.R. China.
Exp Ther Med ; 21(1): 24, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-954685
ABSTRACT
A severe immune response in patients with coronavirus disease 2019 (COVID-19) can cause a potentially lethal unconstrained inflammatory cytokine storm, known as cytokine release syndrome (CRS). The present study provides an overview of the biology underlying CRS and how targeted inhibition of interleukin (IL)-6 signaling may improve outcomes and the survival of patients suffering from COVID-19. Preliminary clinical results have indicated that antagonism of the IL-6 receptor (IL-6R), including with the FDA-approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID-19 while maintaining a good safety profile. The available clinical data support the expansion of clinical trials using IL-6R targeting inhibitors for severe and critical COVID-19 treatment.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Exp Ther Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Exp Ther Med Year: 2021 Document Type: Article