Current and Future Direct-Acting Antivirals Against COVID-19.
Front Microbiol
; 11: 587944, 2020.
Article
in English
| MEDLINE | ID: covidwho-954705
ABSTRACT
The coronavirus disease of 2019 (COVID-19) has caused an unprecedented global crisis. The etiological agent is a new virus called the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). As of October, 2020 there have been 45.4 million confirmed cases with a mortality rate of 2.6% globally. With the lack of a vaccine and effective treatments, the race is on to find a cure for the virus infection using specific antivirals. The viral RNA-dependent RNA polymerase, proteases, spike protein-host angiotensin-converting enzyme 2 binding and fusion have presented as attractive targets for pan-coronavirus and broad spectrum direct-acting antivirals (DAAs). This review presents a perspective on current re-purposing treatments and future DAAs.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Etiology study
Topics:
Vaccines
Language:
English
Journal:
Front Microbiol
Year:
2020
Document Type:
Article
Affiliation country:
Fmicb.2020.587944
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