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Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study.
Hernández, Alberto; Viñals, Montserrat; Pablos, Asunción; Vilás, Francisco; Papadakos, Peter J; Wijeysundera, Duminda N; Bergese, Sergio D; Vives, Marc.
  • Hernández A; Department of Anesthesiology & Perioperative Medicine, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Viñals M; Department of Internal Medicine, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Pablos A; Department of Internal Medicine, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Vilás F; Department of General Surgery, Policlinica Ibiza Hospital, Ibiza, Spain.
  • Papadakos PJ; Department of Intensive Care Medicine, University of Rochester, Rochester, NY, USA.
  • Wijeysundera DN; Department of Anesthesiology & Perioperative Medicine, St Michael Hospital, Toronto, Canada.
  • Bergese SD; Departments of Anesthesiology & Neurological Surgery, Stony Brook University, Stony Brook, NY, USA.
  • Vives M; Department of Anesthesiology & Perioperative Medicine, Hospital Universitari de Girona Dr J Trueta, Girona, Spain. Electronic address: mvives.girona.ics@gencat.cat.
Int Immunopharmacol ; 90: 107261, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-957149
Semantic information from SemMedBD (by NLM)
1. Ozone therapy TREATS Pneumonia caused by SARS-CoV-2
Subject
Ozone therapy
Predicate
TREATS
Object
Pneumonia caused by SARS-CoV-2
2. Ozone therapy TREATS Patients
Subject
Ozone therapy
Predicate
TREATS
Object
Patients
3. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
4. Ozone therapy TREATS Pneumonia caused by SARS-CoV-2
Subject
Ozone therapy
Predicate
TREATS
Object
Pneumonia caused by SARS-CoV-2
5. Ozone therapy TREATS Patients
Subject
Ozone therapy
Predicate
TREATS
Object
Patients
6. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

There is still no specific treatment strategies for COVID-19 other than supportive management.

DESIGN:

A prospective case-control study determined by admittance to the hospital based on bed availability.

PARTICIPANTS:

Eighteen patients with COVID-19 infection (laboratory confirmed) severe pneumonia admitted to hospital between 20th March and 19th April 2020. Patients admitted to the hospital during the study period were assigned to different beds based on bed availability. Depending on the bed the patient was admitted, the treatment was ozone autohemotherapy or standard treatment. Patients in the case group received ozonated blood twice daily starting on the day of admission for a median of four days. Each treatment involved administration of 200 mL autologous whole blood enriched with 200 mL of oxygen-ozone mixture with a 40 µg/mL ozone concentration. MAIN

OUTCOMES:

The primary outcome was time from hospital admission to clinical improvement.

RESULTS:

Nine patients (50%) received ozonated autohemotherapy beginning on the day of admission. Ozonated autohemotherapy was associated with shorter time to clinical improvement (median [IQR]), 7 days [6-10] vs 28 days [8-31], p = 0.04) and better outcomes at 14-days (88.8% vs 33.3%, p = 0.01). In risk-adjusted analyses, ozonated autohemotherapy was associated with a shorter mean time to clinical improvement (-11.3 days, p = 0.04, 95% CI -22.25 to -0.42).

CONCLUSION:

Ozonated autohemotherapy was associated with a significantly shorter time to clinical improvement in this prospective case-control study. Given the small sample size and study design, these results require evaluation in larger randomized controlled trials. CLINICAL TRIAL REGISTRATION NUMBER NCT04444531.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Ozone / Blood Transfusion, Autologous / SARS-CoV-2 / COVID-19 Subject: Ozone / Blood Transfusion, Autologous / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Risk factors Language: English Journal: Int Immunopharmacol Clinical aspect: Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Ozone / Blood Transfusion, Autologous / SARS-CoV-2 / COVID-19 Subject: Ozone / Blood Transfusion, Autologous / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Risk factors Language: English Journal: Int Immunopharmacol Clinical aspect: Etiology / Therapy Year: 2021
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