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HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper.
Fidler, S; Lewin, S; Deeks, S; Sogaard, O S; Vanderkerckhove, L; Collins, S; Kelly, D; Singh, J; Caskey, M; Frater, J.
  • Fidler S; Department of Infectious Disease, Imperial College London and Imperial College NIHR BRC, London, UK.
  • Lewin S; Director of Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia.
  • Deeks S; Department of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General Hospital University of California, USA.
  • Sogaard OS; Department of Infectious Disease, Aarhus University, Denmark.
  • Vanderkerckhove L; Department of Infectious Disease, University of Ghent, Ghent, Belgium.
  • Collins S; HIV I-Base, London, UK.
  • Kelly D; UK CAB, Patient Advocacy Alliance, Manchester, UK.
  • Singh J; CAPRISA, Durban, South Africa.
  • Caskey M; Department of Infectious Disease, Rockefeller University, New York, USA.
  • Frater J; University of Oxford, Oxford NIHR BRC, UK.
J Virus Erad ; 7(1): 100025, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-957267
ABSTRACT
This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others were planned to begin over the next 12 months but most were halted due to the COVID-19 pandemic. We consider the ethics, risks and practical considerations to be taken into account before re-opening HIV cure clinical trials, noting the specific risks of ATI in the context of circulating SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Virus Erad Year: 2021 Document Type: Article Affiliation country: J.jve.2020.100025

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Virus Erad Year: 2021 Document Type: Article Affiliation country: J.jve.2020.100025