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The active GLP-1 analogue liraglutide alleviates H9N2 influenza virus-induced acute lung injury in mice.
Bai, Yu; Lian, Pengjing; Li, Jingyun; Zhang, Zihui; Qiao, Jian.
  • Bai Y; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Lian P; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Li J; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Zhang Z; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Qiao J; Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: qiaojian0913@sina.com.
Microb Pathog ; 150: 104645, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-957311
ABSTRACT
Influenza virus is responsible for significant morbidity and mortality worldwide. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is the major cause of death in influenza virus infected patients. Recent studies indicated that active glucagon like peptide-1 (GLP-1) encoded by glucagon (GCG) gene exerts anti-inflammatory functions. The aim of this study was to determine the potential role of active GLP-1 in H9N2 influenza virus-induced ALI/ARDS in mice. First, we uncovered that GCG mRNA expression levels and GCG precursor protein levels were significantly increased, but total GLP-1 and active GLP-1 levels were decreased in the lungs of H9N2-infected mice. Next, liraglutide, an active GLP-1 analogue, was used to treat infected mice and to observe its effects on H9N2 virus-induced ALI. Liraglutide treatment ameliorated the declined body weight, decreased food intake and mortality observed in infected mice. It also alleviated the severity of lung injury, including lowering lung index, decreasing inflammatory cell infiltration and lowing total protein levels in bronchoalveolar lavage fluid (BALF). In addition, liraglutide did not influence viral titers in infected lungs, but decreased the levels of interleukin-1ß, interleukin-6 and tumor necrosis factor-α in BALF. These results indicated that liraglutide alleviated H9N2 virus-induced ALI in mice most likely due to lower levels of pro-inflammatory cytokines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A Virus, H9N2 Subtype / Acute Lung Injury Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: J.micpath.2020.104645

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A Virus, H9N2 Subtype / Acute Lung Injury Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: J.micpath.2020.104645