Analysis of the predictive factors for a critical illness of COVID-19 during treatment ï¼ relationship between serum zinc level and critical illness of COVID-19.
Int J Infect Dis
; 100: 230-236, 2020 Nov.
Article
in English
| MEDLINE | ID: covidwho-959829
ABSTRACT
OBJECTIVES:
Because most severely ill patients with COVID-19 in our hospital showed zinc deficiency, we aimed to examine the relationship between the patient's serum zinc level and severe cases of COVID-19.METHODS:
Serum zinc <70 µg/dL was defined as the criterion for hypozincemia, and patients continuously with serum zinc <70 µg/dL were classified in the hypozincemia cohort. To evaluate whether hypozincemia could be a predictive factor for a critical illness of COVID-19, we performed a multivariate analysis by employing logistic regression analysis.RESULTS:
Prolonged hypozincemia was found to be a risk factor for a severe case of COVID-19. In evaluating the relationship between the serum zinc level and severity of patients with COVID-19 by multivariate logistic regression analysis, critical illness can be predicted through the sensitivity and false specificity of a ROC curve with an error rate of 10.3% and AUC of 94.2% by only two factors serum zinc value (P = 0.020) and LDH value (P = 0.026).CONCLUSIONS:
Proper management of the prediction results in this study can contribute to establishing and maintaining a safe medical system, taking the arrival of the second wave, and the spread of COVID-19 in the future into consideration.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Zinc
/
Critical Illness
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Int J Infect Dis
Journal subject:
Communicable Diseases
Year:
2020
Document Type:
Article
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