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Correlates of protection against SARS-CoV-2 in rhesus macaques.
McMahan, Katherine; Yu, Jingyou; Mercado, Noe B; Loos, Carolin; Tostanoski, Lisa H; Chandrashekar, Abishek; Liu, Jinyan; Peter, Lauren; Atyeo, Caroline; Zhu, Alex; Bondzie, Esther A; Dagotto, Gabriel; Gebre, Makda S; Jacob-Dolan, Catherine; Li, Zhenfeng; Nampanya, Felix; Patel, Shivani; Pessaint, Laurent; Van Ry, Alex; Blade, Kelvin; Yalley-Ogunro, Jake; Cabus, Mehtap; Brown, Renita; Cook, Anthony; Teow, Elyse; Andersen, Hanne; Lewis, Mark G; Lauffenburger, Douglas A; Alter, Galit; Barouch, Dan H.
  • McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Loos C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Tostanoski LH; Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Atyeo C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Zhu A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Bondzie EA; Harvard Medical School, Boston, MA, USA.
  • Dagotto G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Jacob-Dolan C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Li Z; Harvard Medical School, Boston, MA, USA.
  • Nampanya F; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Patel S; Harvard Medical School, Boston, MA, USA.
  • Pessaint L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Van Ry A; Harvard Medical School, Boston, MA, USA.
  • Blade K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Yalley-Ogunro J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Cabus M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Brown R; Bioqual, Rockville, MD, USA.
  • Cook A; Bioqual, Rockville, MD, USA.
  • Teow E; Bioqual, Rockville, MD, USA.
  • Andersen H; Bioqual, Rockville, MD, USA.
  • Lewis MG; Bioqual, Rockville, MD, USA.
  • Lauffenburger DA; Bioqual, Rockville, MD, USA.
  • Alter G; Bioqual, Rockville, MD, USA.
  • Barouch DH; Bioqual, Rockville, MD, USA.
Nature ; 590(7847): 630-634, 2021 02.
Article in English | MEDLINE | ID: covidwho-960322
ABSTRACT
Recent studies have reported the protective efficacy of both natural1 and vaccine-induced2-7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Models, Animal / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals Language: English Journal: Nature Year: 2021 Document Type: Article Affiliation country: S41586-020-03041-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Models, Animal / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals Language: English Journal: Nature Year: 2021 Document Type: Article Affiliation country: S41586-020-03041-6