Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?
Ultrastruct Pathol
; 44(4-6): 519-523, 2020 Nov 20.
Article
in English
| MEDLINE | ID: covidwho-960391
ABSTRACT
COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with an increasing number of cases and significant mortality worldwide. Clinical trials and extensive studies are being conducted on a large scale for a better understanding of the pathophysiology of this disease and its effect on different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one of the first drugs used. While patients can develop many side effects of HCQ, studies have documented a rare association of long-term HCQ treatment with zebra-like bodies in the ultrastructural examination of kidney biopsies, a finding typically seen in Fabry's disease, as well as in association with chronic HCQ use, among other drugs. We present a similar finding in the postmortem examination of a male in his early seventies with COVID-19 infection, who received five days of HCQ treatment before stopping the medication due to cardiac and renal toxicity.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Phospholipids
/
Organelles
/
Acute Kidney Injury
/
COVID-19 Drug Treatment
/
Hydroxychloroquine
/
Kidney Tubules
Type of study:
Case report
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Ultrastruct Pathol
Year:
2020
Document Type:
Article
Affiliation country:
01913123.2020.1850966
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