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COVID-19 vaccine development: a pediatric perspective.
Kamidani, Satoshi; Rostad, Christina A; Anderson, Evan J.
  • Kamidani S; Department of Pediatrics, Emory University School of Medicine.
  • Rostad CA; Department of Pediatrics, Emory University School of Medicine.
  • Anderson EJ; Center for Childhood Infections and Vaccines (CCIV), Children's Healthcare of Atlanta.
Curr Opin Pediatr ; 33(1): 144-151, 2021 02 01.
Article in English | MEDLINE | ID: covidwho-960640
ABSTRACT
PURPOSE OF REVIEW Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease 2019 (COVID-19), has caused substantial morbidity and mortality. Operation Warp Speed aims to accelerate the development of a safe and effective vaccine by early 2021. Multiple vaccine candidates with reassuring safety and efficacy profiles have advanced to phase 3 clinical trials in adults. The purpose of this review is to describe the burden of COVID-19 in children, to update pediatricians about adult COVID-19 vaccine clinical trials, to discuss the importance of COVID-19 vaccine trials in children and to instill confidence in the established vaccine development and licensure processes. RECENT

FINDINGS:

Children of all ages are at risk for SARS-CoV-2 infection and severe disease manifestations. Children are also susceptible to downstream effects of COVID-19, including social isolation and interruption in education. Developing a pediatric COVID-19 vaccine could prevent disease, mitigate downstream effects and enable children to re-engage in their world.

SUMMARY:

Children could benefit both directly and indirectly from vaccination. In light of the safety and immunogenicity results from recent adult COVID-19 vaccine clinical trials, children should have the opportunity to be included in clinical trials in parallel to ongoing adult phase 3 clinical trials in a manner that is careful, methodical and transparent.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Child / Humans Language: English Journal: Curr Opin Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Child / Humans Language: English Journal: Curr Opin Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article